(초록 예시)

The Characteristics of PEGylated PCDA liposome

Nan Young Ahn, Hye Choi

Department of Biochemistry, College of Natural Science, Chungnam National University, Daejeon, 305-764, Korea

Biosensor system is using a various detection method such as colorimetric, fluorescent and electrochemical method. Recently, the application of polydiacetylene as chemosensor is more investigated than other methods, because these supramolecules undergo a visible color change upon various environmental perturbations such as temperature, pH, ligand-receptor interaction. Polydiacetylene(PDA)s are π-conjugated polymers that have alternating double and triple bond in the main chain. Blue-to-red color transition property of PDA is available as sensor material. We have used the diacetylene monomer 10,12-pentacosadyinoic acid(PCDA) contain carboxylic head groups. This group formed intermolecular hydrogen-bonding networks and PCDA molecules assembled to bilayered liposomes in aqueous solution. These liposomes were irradiated with 254nm UV light to induce polymerization and generated blue-colored polydiacetylene vesicles. Low solubility of PCDA can overcome through Polyethyleneglycol(PEG) introduction. Solubility of synthesized mPEG-PCDA micelle are higher than PCDA vesicle, whereas mPEG-PCDA does not occur polymerization due to their large head group.Also, other properties of PCDA vesicle observed through coating with cationic polymer and heating depend on temperature.

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