Sym. 01. Tumor Microenvironment and Inflammation

October 9 (Wed), 13:00-15:00, Rm. 317

• * by the Tumor Microenvironment Global Core Research Center
• Carol Prives, Ph.D. (Columbia University, USA)
• Jang-Seong Kim, Ph.D. (Korea Research Institute of Bioscience and Biotechnology, Korea)
• Jae-Hong Kim, Ph.D. (Korea University, Korea)
• Jung Weon Lee, Ph.D. (Seoul National University, Korea)
• Seong-Jin Kim, Ph.D. (CHA University, Korea)

The tumor microenvironment and inflammation are key factors in tumorigenesis and especially in tumor progression and the pathogenesis of cancer is largely dependent on its interactions with microenvironmental components. In this session, we invite 5 distinguished scientists working in tumor microenvironment and cancer progression to share their progress in this exciting area and to present a comprehensive view on what tumor microenvironment does in our body. Especially, our session keynote speaker Dr. Carol Prives will present on the complexity of the p53 tumor suppressor network and this distinguished lecture would help us to expand our understanding of the role of p53 in cancer progression. Also, in our session, the roles of TGF-beta, inflammation and integrin during the tumor progression will be discussed.

Organizer: Jae-Hong Kim, Ph.D. (College of Life Sciences and Biotechnology, Korea University, Korea)
Co-Chairs: Jae-Hong Kim, Ph.D. (College of Life Sciences and Biotechnology, Korea University, Korea)
Co-Chairs: Seong-Jin Kim, Ph.D. (CHA Cancer Institute, CHA University, Korea)

Sym. 02. Stem Cell Niche and Cell Therapy

October 9 (Wed), 13:00-15:00, Rm. 318

• * by the WCU Biomodulation, Seoul National University
• Ki-Chul Hwang, Ph.D. (Yonsei University, Korea)
• Takashi Nagasawa, M.D., Ph.D. (Kyoto University, Japan)
• Sang-Hoon Lee, M.D., Ph.D. (Hanyang University, Korea)
• Seungkwon You, Ph.D. (Korea University, Korea)
• Dong Wook Han, Ph.D. (Konkuk University, Korea)

Stem cells hold a great promise for cell-based therapy of human diseases in regenerative medicine. In a past decade, a great and special public attention has been also given to stem cell research. Since the initial stem cell discovery approximately an era ago, various different types of stem cells have been developed as sources for cell therapy such as adult stem cells, embryonic stem cells, induced pluripotent stem cells, and directly reprogrammed cells from somatic cells. Unfortunately, all these cell sources are not likely to be safe to practically apply for the patients who have incurable diseases so far. In this session, we invite distinguished scientists who are working in stem cell niche and cell therapy to share their recent progresses, and to provide ways to translate the basic knowledge to therapeutic implications in human. This session will cover a broad range of stem cell research including the niches for stem cell maintenance in the tissues, the clinical applications of mesenchymal stem cells, the differentiation of pluripotent stem cells into functional cells and their preclinical applications, and the cellular reprogramming of somatic cells to tissue-specific cell types.

Organizer and Chair: SungHoi Hong, Ph.D. (Department of Biomedical Science, College of Health Science, Korea University, Korea)

Sym. 03. Metabolites and Metabolite Signaling in Plant Growth Regulation

October 9 (Wed), 13:00-15:00, Rm. 327

• Michael McManus, Ph.D. (Massey University, New Zealand)
• SungSoo Kim, Ph.D. (Samsung Electronics Co., Ltd. Korea)
• Youn-Il Park, Ph.D. (Chungnam National University, Korea)
• Sang-Dong Yoo, Ph.D. (Korea University, Korea)
• Hak Soo Seo, Ph.D. (Seoul National University, Korea)

Plant genome is enriched with information of metabolic pathways for valuable small molecules controlling diverse organism growth and viability. Thus, it is vastly interesting and important to comprehensively elucidate genetic constituents for primary and secondary metabolic pathways of the plant natural products and unequivocally understand their regulatory principles in organism growth and development. This session brings together experts on primary and secondary metabolisms and metabolic signaling involved in growth and senescence of plants to share and discuss the most recent achievements.
This session promises a seminar program covering most updated exciting researches on biochemical pathways and the genome-inscribed genetic modules for sulfur assimilation in onion and sporopollenin monomer biosynthesis in Arabidopsis. The session also presents interesting new findings on molecular mechanisms of sugars and nitrates signaling as well as their interactions with plant hormones for growth and developmental regulation in Arabidopsis.
Join us as we gather together to explore new ideas, insights and advances in the promising and productive field of life sciences.

Organizer and Chair: Sang-Dong Yoo, Ph.D. (Division of Life Sciences, College of Life Sciences and Biotechnology, Korea University, Korea)

Sym. 04. Cell Fate Control and Nanotechnology

October 9 (Wed), 13:00-15:00, Rm. 401

• * by the Center for RNA Research
• Jong-Young Kwak, M.D., Ph.D. (Dong-A University, Korea)
• Chang-Soo Lee, Ph.D. (Chungnam National University, Korea)
• Jong W Hong, Ph.D. (Auburn University, USA)
• Sungsu Park, Ph.D. (Ewha Womans University, Korea)
• Keesung Kim, Ph.D. (Seoul National University, Korea)

In normal development, cell fate decision is critical for early and late development when embryonic and adult stem cells commit to differentiate into various functional somatic cells. During aberrant development and disease stages, cell fate is abnormally decided by failure of maintenance of a normal gene expression and cellular phenotype. Therefore, if we can develop the technology to control the fate of certain cell types, it should be useful tools for basic understanding developmental biology and developing efficient ways to differentiate certain stem cells into desired somatic cells for cell therapy. In addition the technology can be applied to understand the causes of human disease and develop new drugs for curing it. This session will highlight the latest technological advances in cell fate control through nanotechnology. Here the session gathers nationally and internationally leading experts in the field together to discuss their recent findings in the application of nanotechnology for controlling cell fate, screening new drugs, as well as developing automated cellular bioprocessing.

Organizer and Chair: Kinarm Ko, Ph.D. (Department of Stem Cell Biology, School of Medicine, Konkuk University, Korea)

Sym. 05. Genome-Wide Study of Gene Expression Regulation

October 10 (Thu), 09:00-11:00, Rm. 317

• * by the Basic Research Laboratory for Mitochondrial Anti-Infection Control
• Insuk Lee, Ph.D. (Yonsei University, Korea)
• Christine Vogel, Ph.D. (New York University, USA)
• Jung Kyoon Choi, Ph.D. (Korea Advanced Institute of Science and Technology, Korea)
• Chad Nusbaum, Ph.D. (Broad Institute of MIT and Harvard, USA)

Genome sequencing of various organisms has provided an opportunity to use genome wide study to answer a question how the genes in the whole genome function to explicit biological phenomena. For the last couple of decades, a variety of “omics”-attempts utilizing DNA sequencing, protein biochemistry, microarrays and bioinformatics prove to be useful to help understand what RNA sequences, proteins, and metabolic and signaling pathways DNA sequences in genome transcribe and translate and how they function to exhibit specific phenotypes. The symposium of “the genome-wide study of gene expression regulation” will deliver the current effort of genome-wide approach to help answer a question as to how genes in a given genome generate to a interactive network system in species.

Organizer and Chair: Sun-Kyung Lee, Ph.D. (Department of Life Science, College of Natural Science, Hanyang University, Korea)

Sym. 06 Post-Transcriptional Control of Gene Expression by RNA-Binding Proteins and Non-Coding RNAs

October 10 (Thu), 09:00-11:00, Rm. 318

• * by the National Creative Research Initiatives Center for Chromatin Dynamics
• Jong Heon Kim, Ph.D. (National Cancer Center, Korea)
• Myriam Gorospe, Ph.D. (NIH & NIA, USA)
• Jin Wu Nam, Ph.D. (Hanyang University, Korea)
• Takbum Ohn, Ph.D. (Chosun University, Korea)
• Jae Bok Heo, Ph.D. (Dong-A University, Korea)

Post-transcriptional regulation is the control of gene expression at the RNA level. The study of this area has recently gained more importance due to the increasing evidence that post-transcriptional regulation plays a greater role than previously thought. Recent advances show that various RNA-binding proteins such as HuR, small regulatory RNAs, and long non-coding RNAs have essential roles on this process. RNA-binding proteins regulate the splicing, translation, and stability of RNAs. ELAV-like protein 1 or HuR (human antigen R), for instance, is a protein that is encoded by the ELAVL1 gene in human. This encoded protein, which contains three RNA-binding domains, binds cis-acting AU-rich elements and thereby stabilizes mRNAs. The role of HuR in malignant path will be discussed in this session. MicroRNAs (miRNAs) constitute a class of non-coding RNAs which have essential roles in cellular function and diseases, including cancer. Long non-coding RNAs (lncRNA), which are longer than 200 nucleotides, have recently emerged as an important class of transcript that regulates gene expression at the level of chromatin modification, transcription and post-transcriptional processing. Here, we hope that this session improves your understanding for the post-transcriptional regulation by RNA-binding proteins and non-coding RNAs.

Co-Organizers and Chairs: Jong Heon Kim, Ph.D. (Cancer Cell & Molecular Biology Branch, Research Institute, National Cancer Center, Korea)
Chanseok Shin, Ph.D. (College of Agriculture and Life Sciences, Seoul National University, Korea)

Sym. 07. Neurobiology of Disease

October 10 (Thu), 09:00-11:00, Rm. 327

• * by the Center for Synaptic Brain Dysfunctions, Institute for Basic Science
• Janghoo Lim, Ph.D. (Yale University, USA)
• Inhee Mook-Jung, Ph.D. (Seoul National University, Korea)
• Ja-Hyun Baik, Ph.D (Korea University, Korea)
• Doo-Sup Choi, Ph.D. (Mayo Clinic College of Medicine, USA)
• Akihiro Yamanaka, Ph.D. (Nagoya University, Japan)

Understanding the pathogenesis and pathology of neurological disorders, which are now major burdens on our society, is a major challenge in neuroscience of today. The goal of this symposium is to review progress towards an integrated understanding of molecular, cellular and neuronal basis of different panel of neuronal diseases including neurodegenerative and neuropsychiatric disorders. Speakers in this symposium will present recent findings in studies important for understanding mechanisms elucidating a wide panel of neurological diseases including Alzheimer’s disease but also addiction, alcoholism and sleep disorder. Topics covered will provide diverse neurobiological approaches to delineate the pathological mechanims of diseases from molecules and cells to behavior, obtained by anatomical, electrophysiological and biochemical and molecular techniques using genetically engineered model animals including the latest cutting-edge tools in optogenetics.

Organizer and Chair: Ja-Hyun Baik, Ph.D. (College of Life Sciences and Biotechnology, Korea University, Korea)

Sym. 08. Developmental Biology of Tooth

October 10 (Thu), 09:00-11:00, Rm. 401

• * by the Research Center for Tooth and Periodontal Regeneration
• Jae-Young Kim, Ph.D. (Kyungpook National University, Korea)
• Han-Sung Jung, Ph.D. (Yonsei University, Korea)
• Malcolm L. Snead, D.D.S., Ph.D. (University of Southern California, USA)
• Jung-Wook Kim, D.D.S., Ph.D. (Seoul National University, Korea)
• Eui-Sic Cho, D.D.S., Ph.D. (Chonbuk National University, Korea)

Mammalian teeth are a remarkable and informative system for studying many aspects of developmental biology, from inductive gene expression to pattern formation. The molecular aspect of tooth development is interesting in that it shares many similarities with development of other organs (e.g., lung and kidney) and that of the limb. Thus the tooth organ represents an advantageous system in which to study not only its own development but also developmental pathways in general. Teeth are the only organs dependent on epithelial-mesenchymal interactions to specific terminal cell differentiation. Therefore, to better understand tooth development, the molecular signals that control cell growth, migration, and ultimately cell fate and differentiation also must be considered. This session will feature 5 internationally recognized speakers whose recent findings on tooth enamel & dentin formation, tooth morphogenesis, and genetic defects in dental enamel formation will be presented.

Organizer and Chair: Joo-Cheol Park, D.D.S., Ph.D. (Department of Oral Histology-Developmental Biology, School of Dentistry, Seoul National University, Korea)

Sym. 09. Mitochondria Dynamics and Function

October 10 (Thu), 09:00-11:00, Rm. 402

• * by the Mitochondria Hub Regulation Center
• Daeho Park, Ph.D (Gwangju Instuitute of Science and Technology, Korea)
• Joo-Yong Lee, Ph.D. (Chungnam National University, Korea)
• Yisang Yoon, Ph.D. (Georgia Regents University, USA)
• Pei-Feng Li, M.D., Ph.D. (Chinese Academy of Sciences, China)
• Woong Sun, Ph.D. (Korea University, Korea)
• Yong-Yea Park, Ph.D. (Ajou University, Korea)

Mitochondria in live cells are highly dynamic, showing an interconnected reticular structure that continuously fuse, branch and fragment. It is current understanding that dynamic feature of mitochondrial morphology is crucial for mitochondrial homeostasis as well as cellular integrity. Accordingly, dysfunction of mitochondrial dynamics and function may lead to metabolic disorder, ageing and neurodegenerative diseases. Notably, mitochondrial quality control as a surveillance strategy has also evolved to limit mitochondrial dysfunction and to maintain cellular integrity. This session will feature 6 internationally recognized speakers whose recent findings provide an insight on how mitochondria dynamics contributes to metabolic balance, neuronal development and apoptotic cell clearance. In addition, novel regulatory molecules that control mitochondria dynamics will be presented.

Organizer and Chair: Hyeseong Cho, Ph.D. (School of Medicine, Ajou University, Korea)

Sym. 10. Sensing and Behavior

October 10 (Thu), 15:40-17:40, Rm. 317

• Eun Young Kim, Ph.D. (Ajou University, Korea)
• Jinwoong Bok, Ph.D. (Yonsei University, Korea)
• Junho Lee, Ph.D. (Seoul National University, Korea)
• Piali Sengupta, Ph.D. (Brandeis University, USA)

Sensing various environmental cues and responding by behaving properly are important biological activities to survive and reproduce. In the symposium of “Sensing and Behavior”, we would like to have an opportunity to share the recent development about how sensory neural systems work to gather outside information to direct animal development and behavior. In addition, this symposium will provide clues to understand how sensation systems have been developed through evolutionary path in bilateria. Especially young scientists who hope to gain brilliant insights that can greatly improve their research training are highly encouraged to attend this exciting symposium.

Organizer and Chair: Joohong Ahnn, Ph.D. (Department of Life Science, College of Natural Science, Hanyang University, Korea)

Sym. 11. Beta Cell in Diabetes

October 10 (Thu), 15:40-17:40, Rm. 318

• * by the Diabetes Research Center
• Michael S. German, M.D. (University of California, San Francisco, USA)
• Myung-Shik Lee, M.D., Ph.D. (Samsung Medical Center, Korea)
• Minho Shong, M.D., Ph.D. (Chungnam National University, Korea)
• Takeshi Miyatsuka, M.D., Ph.D.(Juntendo University, Japan)
• Hye Seung JUNG, M.D., Ph.D. (Seoul National University Hospital, Korea

Millions of people suffer from type 2 diabetes and many more are unaware they are at high risk. Although type 2 diabetes is believed to begin with insulin resistance, growing body of evidences support the importance of insulin producing beta cells on the development of type 2 diabetes. During early period of type 2 diabetes, hyperglycemia is not overt because insulin resistance is successfully dealt with by compensatory increase of beta cell mass. Beta cell function showed inverse correlation with the morbidity of type 2 diabetes. Candidate genes for diabetes that have been identified through genome wide diabetes gene screening are genes involved in beta cell. Any of treatment regimens for type 2 diabetes requires beta cell function somehow. Thus, beta cell plays an important role in the development of type 2 diabetes. For better understanding of beta cell, 5 recognized scientists will share their recent findings on beta cell function and the regulation of beta cell mass.

Organizer and Chair: Hail Kim, M.D., Ph.D. (Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Korea)

Sym. 12. Sphingolipid Biology

October 10 (Thu), 15:40-17:40, Rm. 327

• Eun Hee Koh, M.D., Ph.D. (Ulsan University, Korea)
• Tae-Sik Park, Ph.D. (Gachon University, Korea)
• Toshiro Okazaki (Kanazawa Medical University, Japan)
• Hwan-Soo Yoo, Ph.D. (Chungbuk National University, Korea)
• Dong-Soon Im, Ph.D. (Pusan National University, Korea)
• Yong-Seok Oh, Ph.D. (Rockefeller University, USA)

Sphingolipids are mainty found in cellular membranes of all living organism including procaryotic, eucaryotic, mammalian and plants. Recently, sphingolipid biology is an emerging research area deeply related to the important factors on geriatric diseases so called atherosclerosis, inflammatory arthritis, diabetes and cancer. Sphingolipids in membrane have been consideded to be involved in specific functions, such as cell signaling and cell to cell recognition. Recently, simple sphingolipid metabolites, such as ceramide and sphingosine 1-phosphate, have been shown to be essential mediators in the signaling cascades involved in apoptosis, proliferation, stress response, inflammation, autophagy, senescence, and differentiation. This section will provide a current scientific knowledge on the sphingolipid studies in medical, pharmaceutical and other research area.

Organizer and Chair: Yong-Moon Lee, Ph.D. (College of Pharmacy, Chungbuk National University, Korea)

Sym. 13. Transcription and Chromatin

October 10 (Thu), 15:40-17:40, Rm. 401

• * by the Korean Society for Biochemistry and Molecular Biology,
  Center for Cell to Cell Communication in Cancer
• TaeSoo Kim, Ph.D. (Ewha Womans University, Korea)
• Jung-Shin Lee, Ph.D. (Kangwon National University, Korea)
• Joo-Yeon Yoo, Ph.D. (Pohang University of Science and Technology, Korea)
• Nevan Krogan, Ph.D. (University of California, San Francisco, USA)
• Minkyu Kim, Ph.D. (Seoul National University, Korea)

Our genetic information is stored in the form of DNA, but it has to be copied into RNA as an intermediate messenger or non-coding functional unit by an enzyme called RNA polymerase. This copying process (transcription) consists of several steps including initiation, elongation, and termination, each of which is regulated by various mechanisms. Furthermore, eukaryotic transcription has to deal with the chromatin templates, such that histone modifications and chromatin remodeling vastly affect gene expression. Several types of cancers and genetic disorders are often induced by abnormal transcription, highlighting the importance of regulated transcription in preventing diseases. By presenting recent progress from five outstanding speakers, this session will help us to understand how transcription is regulated via histone modifications, specific signaling pathways and large-scale protein-interaction network as well as at the level of termination.

Organizer and Chair: Minkyu Kim, Ph.D. (Department of Biophysics and Chemical Biology, College of Natural Sciences, Seoul National University, Korea)

Sym. 14. Inflammation and Immune Cell Activation

October 11 (Fri), 09:00-11:00, Rm. 317

• * by the Research Center for Human Natural Defense System,
  National Creative Research Initiative Center for Symbiosystem
• Sin-Hyeog IM, Ph.D. (Gwangju Instuitute of Science and Technology, Korea)
• Myoung Ho Jang, Ph.D. (Pohang University of Science and Technology, Korea)
• Mattew Hayden, M.D., Ph.D. (Columbia University, USA)
• Seung-Hyo Lee, Ph.D. (Korea Advanced Institute of Science and Technology, Korea)
• Chang-Duk Jun, Ph.D. (Gwangju Institute of Science and Technology, Korea)

The immune system is important for clearing pathogens that damage host tissues or cells on infection. To function properly, the immune system should detect a wide variety of agents from pathogens and distinguish them from self-antigen originated from our body. This session will feature 5 internationally recognized speakers whose recent findings on the genes and/or cellular factors controlling the immune cell functions and immune cell interactions in the inflammatory responses will be presented. First part of this session is related to immune cell interactions especially in intestine and second part is related to immune mediators and signaling cascades. Last part of this session is related to genes involved in immune cell functions.

Organizer and Chair: Sung-Gyoo Park, Ph.D. (School of Life Sciences, Gwangju Institutue of Science and Technology, Korea)

Sym. 15. Cell and Molecular Biology of Bacterial Infection

October 11 (Fri), 09:00-11:00, Rm. 318

• * by the Infection Signaling Network Research Center
• Kun-Soo Kim, Ph.D. (Sogang University, Korea
• Eun-Kyeong Jo, M.D., Ph.D. (Chungnam National University School of Medicine, Korea
• Se Won Suh, Ph.D. (Seoul National University, Korea
• Michael Otto, Ph.D. (NIH, USA)

Over the last decade, perhaps the most exciting advance in microbiology is the development of a new interface discipline of cellular microbiology. The rapid development of techniques in cellular and molecular biology has transformed research areas across the biological sciences, and microbiology has been influenced most of all. Cellular microbiology has emerged as an integrated field and is revealing how pathogenic bacteria interact with host cells. How the defense mechanisms of host cells compete with pathogenic bacteria in the battle of infection and innate immunity has been the main topic in cellular microbiology. This “cellular and molecular biology of bacterial infection” session is organized to introduce the front line studies in cellular microbiology and popularize this field. Four speakers, working on host-pathogen interactions using multidisciplinary approaches such as microbiology, molecular biology, structural biology and cell biology, are invited in this session. The infection mechanism of three most notorious human pathogenic bacteria, Vibrio, Staphylococcus and Mycobacterium, and the host responses against these bacteria will be presented in this session

Organizer and Chair: Kyeong Kyu Kim, Ph.D. (Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Korea)

Sym. 16. Checkpoint and Genomic Integrity

October 11 (Fri), 09:00-11:00, Rm. 327

• * by the Genomic Instability Research Center
• Ho Chul Kang, Ph.D. (Ajou University, Korea)
• Yonghwan Kim, Ph.D.(Sookmyung Women’s University, Korea)
• Eiji Hara, Ph.D. (Japanese foundation for Cancer Research, Japan)
• Woo-Hyun Chung, Ph.D. (Duksung Women's University, Korea)
• Hyunsook Lee, Ph.D. (Seoul National University, Korea)
• Hyungjin Kim, Ph.D. (Harvard Medical School, USA)

The maintenance of genomic integrity depends on the coordination of checkpoint, DNA repair, cell cycle progression, transcriptional and posttranscriptional regulation and apoptosis, following DNA damage. The integrity of the DNA damage response pathways plays a critical role in checkpoint and genomic integrity. This meeting will present the most recent advances in the field and reveal how a complex network of cellular pathways are involved in DNA damage response. The topics include checkpoint, DNA repair and senescence in response to genotoxic damage.

Organizer and Chair: Jong-Soo Lee, Ph.D. (College of Natural Sciences, Ajou University, Korea)

Sym. 17. Plant Hormones and Development

October 11 (Fri), 09:00-11:00, Rm. 401

• Ken-ichiro Hayashi, Ph.D. (Okayama University of Science, Japan)
• Ildoo Hwang, Ph.D. (Pohang University of Science and Technology, Korea)
• Giltsu Choi, Ph.D. (Korea Advanced Institute of Science and Technology, Korea)
• Hyung-Taeg Cho, Ph.D. (Seoul National University, Korea)

Plant hormone studies are rooted to Julius von Sachs’s (since 1862) and Charles Darwin’s (since 1880) pioneering experiments and formation of concepts of hormones. Beginning with ‘auxin’, now we have numerous hormones and signaling molecules for growth, development, and defense in plants. This symposium session invites four internationally renowned researchers in the plant hormone field. They will be presenting their latest results on hormone signaling and transport issues. In particular, Dr. Ken-ichiro Hayashi from Okayama University, Japan, who is a chemist but not a biologist, will show us how a chemist can be a good friend of a hormone biologist.

Organizer and Chair: Hyung-Taeg Cho, Ph.D. (Department of Biological Sciences, College of Natural Sciences, Seoul National University, Korea)

Sym. 18. HO-1/CO Pharmacology, Physiology and Biology

October 11 (Fri), 09:00-11:00, Rm. 402

• * by the Meta-Inflammation Basic Research Laboratory
• Young-Myeong Kim, Ph.D. (Kangwon National University, Korea)
• Seon-Jin Lee, Ph.D. (Korea Research Institute of Bioscience and Biotechnology, Korea)
• Stefan W. Ryter, Ph.D. (Harvard Medical School, USA )
• Young-Joon Surh, Ph.D. (Seoul National University, Korea)
• Kichurl Chang, Ph.D. (Gyeongsang National University, Korea)

Stress-inducible protein systems represent a common and ubiquitous strategy for maintenance of cellular homeostasis against adverse environments. The enzyme heme oxygenase (HO)-1 generates three separate signaling molecules through the catalysis of heme -carbon monoxide, (CO), biliverdin, and iron- each of which acts via distinct molecular targets to influence cell function. This session focuses on state-of art developments and insights into the impact of HO-1 and CO on vascular angiogenesis, mechanism of regulation of autophagy and inflammation, and as possible target molecule for cholinergic antiinflammation pathway which is responsible for an ensemble of functions that help regulate complex immunological responses to bacterial sepsis.

Organizer and Chair: Ki Churl Chang, Ph.D. (Department of Pharmacology, School of Medicine, Gyeongsang National University, Korea)

Sym. 19. NAD in Health and Disease

October 11 (Fri), 15:40-17:40, Rm. 317

• * by the Center for Metabolic Function Regulation
• Soon Ha Kim, Ph.D. (LG Life Sciences Ltd., Korea)
• Daesoo Kim, Ph.D. (Korea Advanced Institute of Science and Technology, Korea)
• HongSeob So, Ph.D. (Wonkwang University School of Medicine, Korea)
• Woo Jin Park, Ph.D. (Gwangju Institute of Science and Technology, Korea)

NAD+, along with ATP has been proved as an important biological material, which acts as an intracellular energy currency and controls various biological functions such as regulation of enzymatic activities, gene expression, molecular signaling. Recent findings suggest that intracellular NAD+ increase, which caused by calorie restriction and exercise, modulates sirtuins activities, and influences the prevention and treatment of age-related disease, insulin resistance, metabolic syndrome, CVD, inflammation and others.
The four speakers in this session will present therapeutic mechanism research on a novel drug target, or a new drug candidate, how the intracellular NAD/NADH ratio increase and sirtuins activation are related to pharmacological NADH oxidation. The therapeutic treatment effects of NAD modulation will be explained in terms of heart failure, neurodegeneration, age related hearing loss, and necrosis.

Organizer and Chair: Tae Hwan Kwak, M.S. (KT&G Life Sciences Corp., Korea)

Sym. 20. Nuclear Receptors and Human Diseases

October 11 (Fri), 15:40-17:40, Rm. 318

• * by the National Creative Research Initiatives Center for Nuclear Receptor Signals
• Hueng-Sik Choi, Ph.D. (Chonnam National University, Korea)
• David Moore, Ph.D. (Baylor College of Medicine, USA)
• Hun-Taeg Chung, M.D., Ph.D. (Ulsan University, Korea)
• Mi-Ock Lee, Ph.D. (eoul National University, Korea)
• Jae-woo Kim, M.D., Ph.D. (Yonsei University, Korea)
• Sona Kang, Ph.D. (Harvard Medical School, USA)

Nuclear-receptor superfamily has been known as an important player in a variety of pathophysiological responses and maintaining homeostasis. Recent work has highlighted the roles of nuclear receptors in controlling metabolic inflammation (metainflammation) and immunity. In this session, we will discuss the recent advances in the functions of nuclear receptors in regulating immunity, inflammation, and other cellular functions, besides their fundamental roles in the regulation of metabolism. Further, we will extend our understanding of the molecular mechanisms by which nuclear receptors exert regulatory functions in a variety of biologic responses. Finally, this session will provide emerging insights on the potential use of nuclear receptors as excellent targets for various human diseases.

Organizer and Chair: Eun-Kyeong Jo, M.D., Ph.D. (Department of Microbiology, Chungnam National University School of Medicine, Korea)

Sym. 21. Lipoprotein in Atherosclerosis and Metabolic Syndrome

October 11 (Fri), 15:40-17:40, Rm. 327

• * by the Yonsei University Brain Korea 21 PLUS Project for Bioactive Nutrition
• Kyung-Hyun Cho, Ph.D. (Yeungnam University, Korea)
• Jeong Euy Park, M.D., Ph.D. (Sungkyunkwan University, Korea)
• Jaehoon Yu, Ph.D. (Seoul National University, Korea)
• Olivier Meilhac, Ph.D. (INSERM U698, France)
• Jun-ichi Abe, M.D., Ph.D., F.A.H.A. (University of Rochester, USA)
• Hiroshi Mabuchi, M.D. (Kanazawa University, Japan)
• Yun Tae Kim, Ph.D. (Chong Kun Dang Pharmaceutical Corp., Korea)

High levels of low-density lipoprotein (LDL) cholesterol and low levels of high-density lipoprotein (HDL) cholesterol in serum have long been identified as risk factors in the development of atherosclerosis and metabolic syndrome. Oxidative modification of lipoproteins is thought to be a key step between the cardiovascular risk profile and metabolic syndrome. Metabolic syndrome featuring obesity, hyperglycemia, insulin resistance, hypercholesterolemia, hypertriglyceridemia, and hypertension. Oxidized LDL particles are taken up by macrophages in the subendothelial space of the arterial wall, and contribute to foam cell generation, endothelial dysfunction, and inflammatory processes. HDL exerts many beneficial effects for the maintenance of a healthy physiological system, including antioxidant, anti-inflammatory, and anti-thrombotic effects. In this session, we would discuss about lipoprotein-related therapeutic target including apoA-I mimetics, CETP inhibitors, and HDL-blood infusion therapies.

Organizer and Chair: Kyung-hyun Cho, Ph.D. (School of Biotechnology, Yeungnam University, Korea)

Sym. 22. Structural Understanding of the Cell Signaling

October 11 (Fri), 15:40-17:40, Rm. 401

• * by the Translational Research Center for Protein Function Control
• Steve Smerdon, Ph.D. (National Institute for Medical Research, UK)
• Byung-Ha Oh, Ph.D. (Korea Advanced Institute of Science and Technology, Korea)
• Yeon-Gil Kim, Ph.D. (Pohang Accelerator Laboratory, Korea)
• Sangho Lee, Ph.D. (Sungkyunkwan University, Korea)
• Young Jun Im, Ph.D. (Chonnam National University, Korea)
• Changwook Lee, Ph.D. (Ulsan National Institute of Science and Technology, Korea)

Cell signaling is a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity as well as normal tissue homeostasis. Misregulation of cellular signaling is a primary cause of many cancers and other diseases. Structural information on proteins involved in regulation of cellular signaling pathway unravels underlying mechanism at atomic resolution, and will provide an opportunity to develop chemicals that can modulate the signaling pathway to cure diseases. This session will feature 6 internationally recognized speakers whose recent findings on the structural basis for the cellular signaling will be presented.

Organizer and Chair: Soo Hyun Eom, Ph.D. (School of life Science, Gwangju Institute of Science and Technology, Korea)

Sym. 23. Current Development Status of DNA-Based Drugs

October 11 (Fri), 15:40-17:40, Rm. 402

• * by the Medical Research Center for ROS at Kyung Hee Medical School
• Sunyoung Kim, Ph.D. (Seoul National University, Korea)
• Marie-Louise Michel, Ph.D (Institut Pasteur & INSERM, France)
• Seungshin Yu, Ph.D (Seoul National University, Korea)
• Chang-Yuil Kang, Ph.D. (Seoul National University, Korea)
• Seong-Wook Lee, Ph.D. (Dankook University, Korea)
• Richard A. Morgan, Ph.D. (NIH, USA)

A lot of efforts have been made to develop DNA or gene as a new innovative drug over the last 25 years. In particular, DNA, in the form of plasmid, has many attractive features as a drug... Its physico-chemical and biological characteristics are well known, the production and quality control methods are relatively straightforward as compared with other biological materials, and its unique pharmacokinetic and pharmcodynamic features can be useful in many applications of major human diseases. Despite such potential, DNA-based drugs have not yet been successful at entering the actual market. In this session, the current status of development and future perspectives of DNA as a drug will be discussed. This session will also cover the use of genetically modified T cells for cancers presented by Dr. Rick Morgan, a world expert in this field.

Organizer and Chair: Sunyoung Kim, D. Phil. (School of Biological Sciences, College of Natural Sciences, Seoul National University, Korea)

IP-K. Back to the Future: Phenomic Approaches in Drug Discovery

October 9 (Wed), 13:00-15:00, Rm. 402

• * by the Institut Pasteur Korea
• Sungjun Han, Ph.D. (Institut Pasteur Korea, Korea)
• Regis Grailhe, Ph.D. (Institut Pasteur Korea, Korea)
• Yongjun Kwon, Ph.D. (Institut Pasteur Korea, Korea)
• Wang-Shick Ryu, Ph.D. (Yonsei University, Korea)
• Juan Pablo Bifani, Ph.D. (National University of Singapore, Singapore)

Phenotypic screening historically has been the basis for the discovery of new drugs. Compounds are screened in cellular or animal disease models to identify compounds that cause a desirable change in phenotype. Only after the compounds have been discovered, an effort is made to determine the biological target of the compounds. In this session we will highlight various aspects in support for the advantages of phenomic approaches as an innovative strategy in drug discovery

Co-Organizers & Chairs: Michele Liuzzi, Ph.D. (CEO, Institut Pasteur Korea)
Peter Sommer, Ph.D. (Head of Office of Scientific Affairs, Institut Pasteur Korea)