ICKSMCB 2019 / 2019 International Conference of the Korean Society for Molecular and Cellular Biology / September 17(Mon)-19(Wed), 2019 / COEX, Seoul, Korea

Award Lecture

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Academic Research Awards
KSMCB Life Science Award Lecture

September 19 (Wed), 16:40-17:20, Rm. 401

Orphan Nuclear Receptors and Liver Metabolism

Hueng-Sik Choi, Ph.D.
School of Biological Sciences and Technology, Chonnam National University, Korea

Dr. Hueng-Sik Choi is a Professor in the School of Biological Sciences and Technology at Chonnam National University in Gwangju. He received his bachelor’s degree in Biology from Kyung-Hee University and earned his Ph.D. in Dept. of Cell and Developmental Biology at Rutgers University & UMNJ Medical School. During his graduate training, he studied heat shock gene expression in association with cellular aging. He received post-doctoral training in the laboratory of Dr. David D. Moore at Massachusetts General Hospital, Harvard Medical School, and discovered the orphan nuclear receptor, small heterodimer partner (SHP). He joined Chonnam National University as a Full-Time Instructor in 1996 and became Assistant Professor in 1998. He was promoted to Associate Professor in 2002 and Professor in 2008. His research has been focused mainly on the function of SHP in an attempt to elucidate the molecular mechanisms underlying the regulation of gene expression involved in liver metabolism. He first provided the information on structure and location of the human SHP genome. Moreover, he also demonstrated that AMPK signaling regulates SHP gene expression, which in turn inhibits hepatic gluconeogenesis. Recently, he has been intensively involved in studying the basic mechanism of estrogen-related receptor gamma (ERRg) action on metabolic homeostasis to explain molecular etiology of diabetes, obesity, alcoholic liver injury and infectious diseases. As a result, his group discovered that ERRg plays an important role in hepatic gluconeogenesis and lipid metabolism involved in insulin resistance and type 2 diabetes. Lately, he showed that ERRg controls CYP2E1 expression and alcoholic liver injury. In addition, he expended his work to ERRg in iron metabolism and found that ERRg controls bacterial infection by modulating host iron metabolism. Finally, he has gone on to prove that inhibition of ERRg by its inverse agonist could control bacterial infection, and ameliorate alcoholic liver injury and type 2 diabetes. His current studies are focusing on the role of nuclear receptors in an attempt to understand the biological mechanisms that regulate endocrine and metabolic dysfunction and the interorgan communications that coordinate cellular and systemic integration of homeostasis.