September 30 (Mon) - October 2 (Wed), 2019

October 1 (Tue), 12:20-13:10, Rm. 308

IVIM Technology's innovative intravital microscopy system enables dynamic 3D cellular-level imaging of various biological phenomena inside a living animal in vivo. This unique capability allows scientists to directly verify a hypothesis based on data collected in ex vivo or artificial in vitro environments in a natural and physiological in vivo microenvironment at the cellular level. Intravital microscopy has been utilized to image gene expression, protein activity, drug delivery, cell trafficking, cell-cell interaction, and physiological response to external stimuli in a live animal in vivo, which has provided unprecedented insights those were impossible to obtain with conventional static 2D observation ex vivo or in vitro. Additionally, it is possible to directly analyze the delivery and efficacy of new therapeutics such as cell therapy, gene therapy, extracellular vesicles, exosome and various biopharmaceutical products in an in vivo microenvironment.

In this talk, IVIM Technology's All-in-One IntraVital Microscopy system (IVM-C/CM/MS) will be introduced, which can acquire the multi-color microscopic fluorescence images with sub-micron resolution in the living animal model in real time in vivo. The imaging system based on full custom-design, laser-scanning confocal/two-photon microscopy has been extensively optimized for in vivo cellular-level imaging of various internal organs in animal model for human diseases. Intravital microscopic imaging of various organs including skin, liver, spleen, pancreas, kidney, small intestine, colon, retina, lung, heart, lymph node, and bone marrow will be briefly introduced. Subsequently, recent studies utilizing the real-time intravital imaging technique to investigate dynamic cellular-level pathophysiology of various human diseases will be introduced.