학회소개 
| 한국분자·세포생물학회 학술상 생명과학상 수상자 | |
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정종경 (서울대학교 생명과학부) Jongkyeong (JK) Chung is a professor of School of Biological Sciences and also a member of Institute of Molecular Biology and Genetics at Seoul National University. He received his B.S. and M.S. degrees from Seoul National University and earned a Ph.D. degree in cell biology from Harvard University in 1993. During his graduate studies, he firstly demonstrated S6 kinase as a target of PI3 kinase and rapamycin. After completing his postdoctoral research at Dana-Farber Cancer Institute (DFCI) and Harvard Medical School, he joined the faculty of Korea Advanced Institute of Science and Technology (KAIST) in 1996 and served as a professor until 2009. Since he established his own lab, he has been using both mammalian cell system and Drosophila genetics to understand the regulatory mechanism of cell growth and metabolism. His group has generated many important loss-of-function and gain-of-function Drosophila models for PI3 kinase pathway, MAP kinase pathways, TOR pathway, LKB1/AMPK pathway, and p53 pathway to characterize the pathways. Representatively, they include null mutants for p53, RSK, MKP3, PDK1, TOR, FOXO, LKB1, AMPK, and TRAFs. In addition, he has been interested in understanding the pathological mechanism of genetic Parkinson's disease (PD). His group has generated first relevant animal models for PD genes such as Parkin, PINK1, DJ-1, and LRRK2. Using these disease models, his group discovered that two independent PD genes, PINK1 and Parkin genetically and functionally interact and make a novel signaling pathway to control mitochondrial remodeling process. This seminal finding provided a completely new concept for understanding pathological mechanism of both genetic and sporadic PD. Based on these scientific achievements, he has won various awards and honors, such as "Scientist of the Month Award" from Korean government (2006), "Best Research Award" from KAIST (2008), and "Kyung-Ahm Academic Award" (2008). Representative papers -Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. (2006) Nature 441, 1157-1161. -Energy-dependent regulation of cell structure by AMP-activated protein kinase. (2007) Nature 447, 1017-1020. -A metazoan ortholog of SpoT hydrolyzes ppGpp and plays a role in starvation responses. (2010) Nature Structural Molecular Biology 17, 1188-1194. |
| 한국분자·세포생물학회 학술상 Molecules and Cells (M&C) 우수논문상 수상자 | |
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김평현 (강원대학교 의생명과학대학 분자생명과학과) 수상 논문 The PKA/CREB pathway is closely involved in VEGF expression in mouse macrophages. (2007). Mol Cells 23, 23-29. 김평현 교수는 점막IgA항체 생성조절과 점막면역 항상성에 관한 연구를 중점적으로 수행하고 있다. 특히 TGF-b에 의한 IgA 생성과 VEGF 발현 기작을 신호전달/전사조절 수준에서 규명하는 연구를 다년간 수행하였다. Mol Cells (23: 23-29)에 게재된 논문에서는 cAMP-dependent PKA가 CREB을 활성화시키어 VEGF 유전자 발현을 유도한다는 현상과, VEGF promoter에 존재하는 CREB 결합부위를 규명하였다. 김 교수 연구진이 최초로 클로닝한 마우스 VEGF promoter reporter (J Leuko Biol 81:557-566)는 이 분야의 많은 연구그룹에게 제공되고 있다. 본 논문은 Mol Cells의 수준을 향상시키는데 기여하였기에 2010년도 한국분자세포생물학회 <학술상 M&C우수논문상>을 수여한다. |