학회소개 
| 한국분자·세포생물학회 학술상 생명과학상 수상자 | |
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이한웅 (연세대학교 생명시스템대학 생화학과) Professor Lee has made a great contribution to the general biomedical field by boosting and spreading mouse molecular genetics in Korea for last 17 years and also by persuading the government. He has provided hundreds of transgenic/knockout mice to over 100 scientists in Korea and abroad to help their in vivo research. He has organized Korean Society of Mouse Genomics under the Korean Society for Molecular Cell Biology and has been arranging "Practical Courses for Genetically-Engineered Mouse Technology" since 2007 to boost in vivo mouse research in Korea. Very recently, he succeeded in developing the technology of mouse production by adopting artificial endonucleases called TALEN and CRISPR/Cas9 systems (Nature Biotechnology 2013, Genome Research 2014), revolutionizing the field of knockout mouse technology. His research has been focused on the basic mechanistic study on cell cycle inhibitors (Cell 1996) and telomerase (Cell 1997, Nature 1998). He is a pioneer of elucidating the non-telomeric function of telomerase which may eventually decipher the enigma of aging and cancer (Oncogene 2008). He is currently studying on the molecular mechanism and thereby physiological role of telomerase-related and other genes (Cell Reports 2014). He is recently reorienting the focus of his research into more direct clinical application of basic research such as drug resistance and gene/cell therapy. Representative papers |
| 한국분자·세포생물학회 학술상 Molecules and Cells (M&C) 우수논문상 수상자 | |
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안진흥 (경희대학교 작물바이오텍연구센터) 수상 논문 Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification Because staple foods such as cereal grains are poor sources of key mineral nutrients, their consumption may cause micronutrient deficiencies. For example, a low supply of iron (Fe) is a worldwide, prevalent problem that leads to poor health in general and impaired development in women and children in particular. Various strategies have been followed to tackle these mineral deficiences, such as encouraging diversification in diet as well as supplementing and fortifying processed foods. Because micronutrients in human diets ultimately come from plant sources, malnutrition of essential minerals is a significant public health concern. Utilization of nicotianamine (NA), a chelator of metal cations, is a strategy for improving Fe concentrations. Nicotianamine is biosynthesized from three molecules of S-adenosyl methionine (SAM) via NA synthase (NAS). By increasing the expression of NAS, we fortified the level of bioavailable iron in rice seeds. Activation of iron deficiency-inducible OsNAS2 resulted in a rise in Fe content (3.0-fold) in mature seeds. Its ectopic expression also increased that content. Enhanced expression led to higher tolerance of Fe deficiency and better growth under elevated pH. Mice fed with OsNAS2-D1 seeds recovered more rapidly from anemia, indicating that bioavailable Fe contents were improved by this increase in OsNAS2 expression. |