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4. ÀÏõ±â³ä°­Á (Ilchun Memorial Lecture)

 
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Dr. Lee began studying basic science as a graduate student and a research assistant at the Department of Pharmacology at Yonsei University after finishing medical school at the same University in 1990. He moved to Dallas, Texas in 1996, and worked as a research fellow in the Department of Physiology at University of Texas Southwestern Medical School. In early 1999, he came back to Yonsei and became a faculty member at the Department of Pharmacology. He has served as the Director of the Pharmacogenomic Research Center for Membrane Transporters (PRCMT) at Yonsei since 2003 and has been the principal investigator of many important research projects including the National Creative Research Initiatives on Membrane Transporters starting from 2013. He has focused his research on the following three topics: i) molecular mechanism of transmembrane transport of ions and small molecules, ii) genetic variations in the membrane transporter genes and their implications in human disease, and iii) intracellular trafficking and processing of membrane transporting proteins.

Representative papers
- Gee HY, Noh SH, Tang BL, Kim KH, Lee MG. (2011). Rescue of ΔF508-CFTR trafficking via a GRASP-dependent unconventional secretion pathway. Cell 146: 746-760.
- Won H, Lee HR, Gee HY, Mah W, Kim JI, Lee J, Ha S, Chung C, Jung ES, Cho YS, Park SG, Lee JS, Lee K, Kim D, Bae YC, Kaang BK, Lee MG, Kim E. (2012). Autistic-like social behaviour in Shank2-mutant mice improved byrestoring NMDA receptor function. Nature 486: 261-265.
- Lee MG, Ohana E, Park HW, Yang D, Muallem S. (2012). Molecular mechanism of pancreatic and salivary gland fluid and HCO3- Secretion. Physiol Rev. 92: 39-74.
- Jung J, Nam JH, Park HW, Oh U, Yoon JH, Lee MG. (2013). Dynamic modulation of ANO1/TMEM16A HCO3- permeability by Ca2+/calmodulin. PNAS USA 110: 360-365.
- Park HW, Nam JH, Kim JY, Namkung W, Yoon JS, Lee JS, Kim KS, Venglovecz V, Gray MA, Kim KH, Lee MG. (2010). Dynamic regulation of CFTR bicarbonate permeability by [Cl-]i and its role in pancreatic bicarbonate secretion. Gastroenterology 139: 620-631.

   

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