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4. ÀÏõ±â³ä°­Á (Ilchun Memorial Lecture)

 
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·ùÈÆ (Boston University School of Medicine, USA)

Dr. Hoon Ryu earned his doctoral degree from Chonbuk National University, South Korea. He completed a postdoctoral research fellowship and was appointed Instructor of Neurology at Beth Israel Deaconess Medical Center and Harvard Medical School in 1999. He joined the Department of Neurology at Boston University School of Medicine in 2004 as an Assistant Professor. Currently, he is an Associate Professor and an Investigator of the Boston University Alzheimer's Disease Center and VA Boston Healthcare System where he is the director of the laboratory for Neuronal Gene Regulation and Epigenetics. Dr. Ryu studies how altered chromatin plasticity is associated with the brain disorders including Alzheimer's disease (AD), Huntington's disease (HD), and chronic traumatic encephalopathy. In this context, he has found that abnormal heterochromatin condensation is linked to the pathogenesis of AD and HD. He further works on identification of biomarkers, determination of molecular genetic or epigenetic mechanisms, and development of therapeutics for treating brain disorders. He has published over 100 original reports. Dr. Ryu is currently a recipient of the Independent Investigator awards (RO1) from the National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS). He was awarded Huntington's Disease Society of America (HDSA) grant, CHDI Foundation Grant, American Parkinson Disease Association (APDA) Pilot Study Award, and National Center for Drug Discovery in Neurodegeneration (NCDDN) Fellowship Award. He serves as an Academic Editor of several journals including PLOS ONE and Experimental Neurobiology and an ad-hoc reviewer in NIH.

Representative papers
- Jo S, Yarishkin O, Hwang YJ, Woo DH, Park M, Kim T, Lee J, Chun H, Park HJ, Bae JY, Park SJ, Lee H, Yoon B-E, Shim IS, Bae YC, Cho J, Kowall NW, Ryu H, Hwang E, Kim D, and Lee CJ. Glial GABA masks memory in mouse models of Alzheimer's disease. (2014) Nat. Med. 20:886-896.
- Hwang YJ, Han DH, Kim KY, Min S-J, Kowall NW, Yang L, Lee J, Kim YS, and Ryu H. ESET methylates UBF at K232/254 and regulates nucleolar heterochromatin plasticity and rDNA transcription. (2014) Nucleic Acids Res. 42:1628-1643.
- Koh D-I, Han D, Ryu H, Choi W-I, Kim M-K, Jeon B-N, Kim Y, Kim JY, Parry L, Clarke AR, Reynolds AB, and Hur M-W. KAISO, a critical regulator of p53 mediated transcription of CDKN1A and apoptotic genes. (2014) Proc. Natl. Acad. Sci. USA. 111:15078-15083.
- Kim YH, Kim KY, Hwang YJ, Kowall NW, Lee SB, Lee J, and Ryu H. Uvrag targeting by MiR-125a and MiR-351 modulates autophagy associated with EWS deficiency. (2015) Autophagy. 11:796-811.
- Hong C, Kwak M, Myeong J, Hwang YJ, Ha K, Kim I-G, Jeon J-H, Ryu H*, So I*. Increased TRPC5 glutathionylation contributes to striatal neuron loss in Huntington's disease. (2015) Brain. 2015 Jun 30. pii: awv188. [Epub ahead of print]

   

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