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2. KSMCB ¿©¼º»ý¸í°úÇÐÀÚ»ó (KSMCB Award for Women in Life Science)

 
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V. Narry Kim has made major contributions to our understanding of RNA biology. Her group has been investigating how microRNAs are made and regulated, and what microRNAs do to modulate cell signaling in cancer and embryonic stem cells. Her research group found and studied several key factors in the microRNA pathway including Drosha, DGCR8, Lin28, and TUTases, and discovered pluripotent stem cell-specific microRNAs such as human miR-302 cluster, miR-369 cluster, and miR-371 cluster. More recently, Kim has made important progresses into understanding RNA regulation through translation, RNA tailing and decay. In particular, her group developed a technology that allows genome-wide study of RNA tail, and revealed important roles of RNA uridylation and adenylation in gene regulation.

Narry Kim serves as the Director of RNA Research Center at Institute for Basic Science and a Professor of Biological Sciences at Seoul National University. She received her Ph.D. in 1998 from Oxford University, UK, where she studied the functions of retroviral proteins in the construction of gene transfer vectors in the Kingsman lab. She then carried out her postdoctoral research on mRNA surveillance in the laboratory of Gideon Dreyfuss at the University of Pennsylvania, USA. She set up her own research group at Seoul National University in 2001. Narry Kim received L'Oreal-UNESCO Women in Science Award (2008), the Ho-Am Prize in Medicine (2009), and the Korea S&T Award (2013), and was elected as Foreign Associate of European Molecular Biology Organization (EMBO, 2013), Foreign Associate of National Academy of Science (NAS, 2014), and Member of Korean Academy of Science and Technology (KAST, 2014).

Representative papers
- S. C. Kwon, T. A. Nguyen, Y.-G. Choi, M. H. Jo, S. Hohng, V. N. Kim, J.-S. Woo (2016) "Structure of Human DROSHA" Cell, 164(1-2):81-90.
- J. Cho, N.-K. Yu, J.-H. Choi, S.-E. Sim, S. J. Kang, C. Kwak, S.-W. Lee, J. Kim, D. I. Choi, V. N. Kim, and B.-K. Kaang (2015) "Multiple repressive mechanisms in the hippocampus during memory formation" Science, 350(6256):82-87.
- J. Lim, M. Ha, H. Chang, S. C. Kwon, D.K. Simanshu, D.J. Patel, and V. N. Kim (2014) "Uridylation by TUT4 and TUT7 marks mRNA for degradation" Cell, 159(6):1365-1376. - Heo, M. Ha, J. Lim, M.-J. Yoon, J.-E. Park, S. C. Kwon, H. Chang and V. N. Kim (2012) "Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs" Cell, 151: 521-532.
- Y. Lee, C. Ahn, J. Han, H. Choi, J. Kim, J. Yim, J. Lee, P. Provost, O. Radmark, S. Kim,V. N. Kim (2003) "The nuclear RNase III Drosha initiates microRNA processing" Nature, 425(6956):415-9.

   

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