ICKSMCB 2015 / International Conference of the Korean Society for Molecular and Cellular Biology / Oct.9 (Wed) ~ 11 (Fri), 2013 / COEX, Gangnam, Seoul, Korea

Nobel Laureate Lecture

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ATCC: Recent Advances in the Development of in-vitro Models for Cell & Molecular Biology (Koram Biotech)

September 13 (Wed), 12:20-13:10, Rm. 307

Recent Advances in the Development of In-vitro Models for Cell and Molecular Biology Applications

Mindy Goldsborough, Ph.D.
Chief Science & Technology Officer, ATCC, USA

ATCC (American Type Culture Collection) has been engaged in a multifaceted approach to enhance and modernize its cell biology portfolio in order to provide more relevant cell and molecular models to aid in basic, translational and pre-clinical research. Our mission is to provide the most well characterized and authenticated primary cells, immortalized primary cell lines, continuous cell lines and associated products to the global research community.

With the vast collection of existing ATCC cell lines as starting material, ATCC is in a unique position to develop meaningful in-vitro models in the most relevant cell line background. Our efforts have resulted in a growing collection of well characterized and authenticated CRISPR gene edited isogenic cell lines in highly relevant cell backgrounds. These cell lines faithfully demonstrate the characteristics of the human cancers they have been modeled after, such as drug resistance. In addition to gene editing, ATCC is utilizing advanced 2D and 3D cell culture methods such as organoids, CRC (conditionally reprogramed cells), neurospheres and spheroid culture to create improved in-vitro models.

To address more molecular biology based research, ATCC has developed an extensive collection of cancer cell line panels that have been extensively characterized for cancer mutation biomarkers and cell signaling pathway expression levels. These pre-selected panels enable broader and more in-depth questions to be asked within cancer types, biomarker families or a cell signaling pathways.