ICKSMCB 2020 / 2020 International Conference of the Korean Society for Molecular and Cellular Biology / September 17(Mon)-19(Wed), 2020 / COEX, Seoul, Korea


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October 5 (Mon), 2020

Sym.01 Cilia Signaling and Signal Perception
October 5 (Mon), 13:00-15:10, Channel A
The cilium plays diverse roles and considered as a clinically important organelle with ciliary dysfunction underlying several human syndromes collective called the ciliopathies. Ciliopathies are associated with several human syndromes and exhibit pleomorphic phenotypes affecting nearly every tissue and organ system. As the cilia have emerged to signaling hub for diverse cellular signaling, this session titled "Cilia signaling and signal perception" will focus on the recent advances in mechanistic insights of the ciliary study.

Organizer: Ki Woo Kim, Ph.D. (Yonsei University, Korea)
Chairs: Jinwoong Bok, Ph.D. (Yonsei University, Korea)
Heon Yung Gee, M.D., Ph.D. (Yonsei University, Korea)
Name(Eng) Organization Nationality Title
Seok-Yong Choi Chonnam National University Medical School Korea The Wnt-PLC-IP3-Connexin-Ca2+ axis maintains the ependymal motile cilia in the zebrafish spinal cord
Nicolas F. Berbari Indiana University-Purdue University USA Neuronal cilia in feeding behavior
Joon Kim Korea Advanced Institute of Science and Technology (KAIST) Korea Roles of the ciliopathy protein CPLANE1 in mitosis and neurogenesis
Hyunjoon Kim Seoul National University Korea Identification of the FTO-FOXJ1 axis as a conserved regulatory module of embryonic and homeostatic motile ciliogenesis
Yoojoong Kim Pohang University of Science & Technology (POSTECH) Korea Structural Basis for Activation of the Heterodimeric GABAB Receptor
Sym.02. Noncanonical Nucleic Acids: from Structure to Cellular Functions
*Co-organized by KSBMB
October 5 (Mon), 13:00-15:10, Channel B
Most DNA in the genome is considered to be present as a B-form, but number of evidences support that DNA structures are highly polymorphic. Therefore, many sequence-specific noncanonical DNA (ncDNA) or non-B-DNA conformations transiently exist, often in response to changes in the cellular environment or when bound to proteins. A number of ncDNA structures, including triplexes, left-handed DNA, bent DNA, cruciforms, nodule DNA, flexible and writhed DNA, G-quartet (tetraplexes), slipped structures, and sticky DNA, have been discovered approximately one new conformation every 3 years for the past 35 years. ncDNAs are involved in various cellular events including chromatin remodeling, replication, transcription and recombination, and thus its presence or mutation is relevant to the various disease including tumors. In addition, it is verified that many genetic diseases are closely related to ncDNA. Therefore, it is considered that regulation of ncDNA formation is crucial to understand its cellular function and to develop a novel strategy for curing the related diseases. In this session current progress on the structure, function and modulation of ncDNA will be introduced.

Organizer & Chair : Kyeong Kyu Kim, Ph.D. (Sungkyunkwan University, Korea)
Name(Eng) Organization Nationality Title
Sua Myong Johns Hopkins University USA R-loop induced G-quadruplex in non-template promotes transcription by successive R-loop formation
IL-Doo Hwang Pohang University of Science and Technology (POSTECH) Korea In vivo role of RNA G-quadruplex in plants
Jin-Hyun Ahn Sungkyunkwan University Korea Regulation of CMV infection by G-quadruplex
Kyun-Hwan Kim Sungkyunkwan University Korea Application of G-quadruplex to control viral replication
Chin-Ju Park Gwangju Institute of Science and Technology (GIST) Korea Interaction between the RecQ C-terminal domain of human Bloom syndrome protein and G-quadruplex DNA 
Sangin Kim Ulsan National Institute of Science and Technology (UNIST) Korea ATAD5 restricts R-loop formation through PCNA unloading and RNA helicase maintenance at the replication fork
Sym.03. Human Microbiome, Probiotics, and Pharmabiotics
October 5 (Mon), 13:00-15:10, Channel C
The microbiome, comprised of the microbiota and its collective genomes called the metagenome, is an integral part of our body. Members of the microbiota include bacteria, archaea, microbial eukaryotes (protists, fungi, etc.), and respective viruses. Recent studies reveal that a myriad of members, mutualistic, commensal, or pathogenic, of the human microbiome play pivotal roles in health and disease by producing diverse macromolecules and metabolites. Not only are they important in nutrient digestion and gastrointestinal health, but they are also intimately and intricately involved in metabolism, immunity, development, circulation, and behavior, and modulate them in many ways. Some of the diseases affected by the microbiome include metabolic diseases (obesity, type 2 diabetes), immune-related diseases (inflammatory bowel disease, asthma, rheumatoid arthritis), gastrointestinal diseases, liver diseases, cardiovascular disease, various cancers, and neural/mental disorders. In the session, recent progress and achievements in human microbiome research and the consequent discovery of pharmabiotics candidates that are derived from the human microbiome and have pharmacological efficacy for maintaining health or treating diseases will be reported and prospects for further commercial development of probiotics and pharmabiotics, natural or genetically modified, will be discussed.

Organizer & Chair : Jihyun F. Kim, Ph.D. (Yonsei University, Korea)
Name(Eng) Organization Nationality Title
Matthew W. Chang National University of Singapore Singapore Engineering microbes to rewire host-microbiome interactions
Mi-Na Kweon Asan Medical Center Korea Regulation of microbiota-derived metabolites on gut homeostasis
Ara Koh Sungkyunkwan University Korea Role of the gut microbiota and its products on host metabolism
Soon-Kyeong Kwon Gyeongsang National University Korea Pharmabiotics for gastric illness and plant infection
Sym.04 Histone Modification in Senescence and Cancer
October 5 (Mon), 13:00-15:10, Channel D
Histone modifications are intimately associated with cellular differentiation and senescence whose abnormal regulation underlies cancer incidence and progression. Accumulating evidence have shown that dysregulation of histone modification is critical for cancer development. In order to pave the way for overcoming cancer, this symposium will discuss recent progression on molecular details of histone modification-mediated regulation of senescence and cancer.

Organizers & Chairs : Hyungsung Park, Ph.D. (University of Seoul, Korea)
Jung-Ae Kim, Ph.D. (Korea Research Institute of Bioscience and Biotechnology (KRIBB), Korea)
Name(Eng) Organization Nationality Title
Peter Lewis University of Wisconsin USA H3 K27M and EZHIP impede H3K27-methylation spreading by inhibiting allosterically stimulated PRC2
Kyung-Min Noh EMBL-Heidelberg Germany Function of histone H3.3 residue in physiology and cancer
Jaehoon Kim Korea Advanced Institute of Science and Technology (KAIST) Korea Characterization of histone H3K4 methyltransferase activities of human KMT2 complexes
Chang-Young Jang Sookmyung Women's University Korea Function of histone H3R2 methylation in chromosome condensation
Cheol-Jung Lee Catholic University of Korea Korea The E3 ligase FBXW7 promotes ubiquitination-mediated proteolysis of STAT2 to suppress melanoma proliferation and colony formation.
Sym.05 Data-Driven Cancer Research in Translation
October 5 (Mon), 13:00-15:10, Channel E
Recent progress in sequencing technology empower scientists to accelerate cancer science. These data accelerate cancer science by providing multi-layered data sets from genomics to phenomics. Here we invited most well-known scientists from data-driven cancer science field who transformed real world data to molecular level. We will provide evidence that integration of multi-omics data can solve the complexity of cancer heterogeneity and disease progression.

Organizer & Chair : Jong Bae Park, Ph.D. (National Cancer Center, Korea)
Name(Eng) Organization Nationality Title
Antonio Iavarone Columbia University USA Classification and Precision Therapy of Glioblastoma
Do-Hyun Nam Sungkyunkwan University Korea Precision oncology based on drug screening
Jae-Ho Cheong Yonsei University Korea Multi-layer molecular information guided translational cancer medicine for refractory cancers
Dongwan Hong Catholic University of Korea Korea A multifaceted interpretation in cancer big data
Dong Young Kang Konkuk University Korea The Inhibitory Mechanisms of Tumor PD-L1 Expression by Natural Bioactive Gallic Acid in Non-Small-Cell Lung Cancer (NSCLC) Cells
Sym. 06 Recent Advances in Peroxisome-Related Human Health
October 5 (Mon), 13:00-15:10, Channel F
Subcellular organelles including ER, mitochondria, lysosomes, and peroxisomes have intensively been studied individually as well as interactively. Among these, peroxisomes and their association to other organelles have been focused to reveal their specific roles in cellular metabolism and thus to answer human diseases wherein the involvement of the organelle has been assumed. This session will present cutting-edge research data from the studies of peroxisome and related organelles that were conducted in leading laboratories in Korea in addition to from a worldrenowned laboratory. Specifically, we will focus on novel metabolic roles of peroxisomes in the development of human diseases.

Organizer : Hunjoo Ha, Ph.D. (Ewha Womans University, Korea)
Chairs : Raekil Park. M.D., Ph.D. (Gwangju Institute of Science & Technology (GIST), Korea)
Seong-Kyu Choe, Ph.D. (Wonkwang University, Korea)
Name(Eng) Organization Nationality Title
Raekil Park Gwangju Institute of Science & Technology (GIST) Korea TMEM135 regulates primary ciliogenesis through modulation of intracellular cholesterol distribution 
Jae Bum Kim Seoul National University Korea Novel roles of peroxisome in fat tissue for energy balance
Kyu-Sun Lee Korea Research Institute of Biotechnology and Bioscience (KRIBB) Korea Drosophila genetic model for studying peroxisome dynamics
Yukio Fujiki Kyushu University Japan Peroxisome biogenesis and human disorders
Do-Hyeon Kim Pohang University of Science & Technology (POSTECH) Korea Clathrin-coated Pits are a Shredded Organelle Pre-sorting Receptors on a Plasma Membrane

October 6 (Tue), 2020

Sym. 07 Precision Plant Breeding & Molecular Farming
October 6 (Tue), 09:00-11:10, Channel A
Plants influence significantly in our lives as a source of food and medicine as well as industrial materials. Plant scientists are trying to effectively produce safe and sustainable food, feed, and food ingredients using precision breeding techniques, and also produce biobetter pharmaceutical proteins from plants (the term biobetter refers to a recombinant protein drug that is in the same class as an existing biopharmaceutical but is not identical; it is improved over the original). In this symposium, excellent scientists will present their research on current advances in applied plant science, such as the green vaccine, plant-derived biobetter medicinal protein, molecular breeding for phytochemical production, and genome editing for precision breeding.

Organizer & Chair : Young Hee Joung, Ph.D. (Chonnam National University, Korea)
Name(Eng) Organization Nationality Title
Kisung Ko Chung-Ang University Korea Expression and glycomodification of recombinant vaccines and antibodies in plant
Eun-Ju Sohn BioApplications Inc. Pohang Korea Green Vaccine; plant-made subunit vaccine sheds new lights on animal infectious disease eradication
Tae-Jin Yang Seoul National University Korea Genome sequence & molecular breeding for Panax ginseng
Holger Puchta Botanical Institute,
Karlsruhe Institute of Technology
Germany CRISPR/Cas Mediated Chromosome Engineering
Hyun Seob Cho Pohang University of Science & Technology (POSTECH) Korea Regulation of developmental plasticity via formation of membrane-less organelle in root
Sym. 08 Transposable Elements from Evolution to Disease
October 6 (Tue), 09:00-11:10, Channel B
Transposable elements also known as "jumping genes" or transposons, are sequences of DNA that move (or jump) from one location in the genome to another. Transposable elements have dynamically moved and changed genomes to affect evolution and diseases significantly. This symposium deals with recent studies about Transposable elements from evolution to diseases.

Organizer & Chair : Hee-Jae Cha, Ph.D. (Kosin University, Korea)
Name(Eng) Organization Nationality Title
Christopher Faulk University of Minnesota USA Absence of signatures of horizontal transfer in pairwise comparisons of human and domestic animal transposomes
Jin Hoe Huh Seoul National University Korea Hybrid genome stabilization by DNA methylation of retrotransposons in xBrassicoraphanus
Jungnam Cho John Innes Centre & Chinese Academy of Sciences China Translational Inhibition and Phase Separation Primes the Epigenetic Silencing of Transposons
Jinju Han Korea Advanced Institute of Science and Technology (KAIST) Korea Regulation of L1 activity in neural cells
Sunwoo Min Ajou University Korea The chromatin remodeler RSF1 coordinates epigenetic marks for DSB repair and transcriptional repressio
Sym.09 Metabolism and Cell Death
October 6 (Tue), 09:00-11:10, Channel C
To be or not to be, that is an important issue in our healthy life. There are very interesting connections between cell death and metabolism but still are elusive. In this symposium you can meet four excellent international scientists (from UK and Korea) to present the most recent studies on mammalian cellular homeostasis regulators in metabolism, cell death and metabolic diseases.

Organizer & Chair : In Hye Lee, Ph.D. (Ewha Womans University, Korea)
Name(Eng) Organization Nationality Title
Kevin Ryan Cancer Research UK Beatson Institute UK Targeting tumor metabolism
Jaewhan Song Yonsei University Korea The new roles of MYC in necroptosis
Young-Keun Jung Seoul National University Korea DR4-Ser424 O-GlcNAcylation Promotes Sensitization of TRAIL-Tolerant Persisters and TRAIL-Resistant Cancer Cells to Death
In Hye Lee Ewha Womans University Korea Exploring the molecular connection between metabolism, DNA damage response and cell death
Won Gun Choi Korea Advanced Institute of Science and Technology (KAIST) Korea The role of serotonin signaling through htr2b in visceral adipose tissue
Sym.10 Neurobiology of Addiction and Reward
October 6 (Tue), 09:00-11:10, Channel D
Understanding how cellular and synaptic mechanisms within neural circuits produce reward & addiction behaviors is a fundamental goal of neuroscience. To achieve that goal, we need deep appreciation of these behavior as well as a detailed knowledge of the underlying mechanisms. This symposium will provide the field of reward & addiction research a unique opportunity to meet colleagues, to nurture young investigators, to drive a diverse work force in the field, and to promote advances in the field toward new and definitive treatments of the related disorders.

Organizers & Chairs : Joung Hun Kim, Ph.D. (Pohang University of Science & Technology (POSTECH), Korea)
Ja-Hyun Baik, Ph.D. (Korea University, Korea)
Name(Eng) Organization Nationality Title
Ja-Hyun Baik Korea University Korea Dopaminergic circuit for food reward
Choon-Gon Jang Sungkyunkwan University Korea TRPA1 as a target for addictive disorders 
Yan Dong University of Pittsburgh USA Synaptic remodeling in cocaine memories
Joung Hun Kim Pohang University of Science & Technology (POSTECH) Korea Dopaminergic regulation of cholinergic interneurons for cocaine addiction
Dong Il Choi Seoul National University Korea Synaptic correlates of associative fear memory in the lateral amygdala
Sym. 11 Hippo and Wnt Signaling in Diseases
October 6 (Tue), 09:00-11:10, Channel E
Cells recognize various signals from outside and induce diverse cellular signaling pathways. Mis regulation of cellular signaling steps leads to human diseases such as cancers. Wnt and Hippo signalings are key signaling pathways for the maintenance of cellular homeostasis. In this session, current aspects of Wnt and Hippo signalings will be discussed.

Organizer & Chair : Eekhoon Jho, Ph.D. (University of Seoul, Korea)
Name(Eng) Organization Nationality Title
Eekhoon Jho University of Seoul Korea TFEB is a terminal regulator of Wnt signaling
Dawang Zhou Xiamen University China Metabolic regulation of the hippo signaling pathway
Boksik Cha Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF) Korea Transcriptional co-activators YAP and TAZ regulate lymphatic vascular development
David Virshup Duke-NUS Medical School Singapore Upstream regulation of Wnt signaling: biology and therapy
Hee Chan Yoo Yonsei University Korea SLC1A5 Variant Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells
Sym.12 Translational Research for Biomedical Application of Nucleic Acid-Based Therapeutics
October 6 (Tue), 09:00-11:10, Channel F
With advancement of nucleic acid science, convergence of basic research on nucleic acid and biomedical science has provided the basis, for various breakthroughs and follow-up applications of nucleic acid-based medicine. This new advancement is becoming increasingly relevant to our lives. This session will look into recent translational research and applications in nucleic acid-based therapeutics in the health problem. In particular, this session will provide a successful example of translational research using nucleic acid-based therapeutics in health problems. From this session, audience can easily follow-up recent innovative researches and applications in the fields of nucleic acid-based therapeutics.

Organizer & Chair : Jeong Hun Kim, M.D., Ph.D. (Seoul National University, Korea)
Name(Eng) Organization Nationality Title
Dong Hyun Jo Seoul National University Korea Overview of biomedical application of nucleic acid-based therapeutics
Hironori Nakagami Osaka University Japan Development of therapeutic vaccine for chronic diseases
Young-Kook Kim Chonnam National University Korea Study of Regulatory Non-coding RNAs in Disease Models
Jeong Hun Kim Seoul National University Korea In vivo genome editing for vision
Mohammad Hassan Baig Yonsei University India SARS-COV-2 spike protein mutation and their effect on binding with host ACE-2 receptor protein: Correlation with worldwide establishment of COVID 19 in various countries
Sym.13 Biotic and Abiotic Stress in Plants
October 6 (Tue), 15:10-17:20, Channel A
Plants face various biotic and abiotic stresses. In order to protect themselves from these stresses, plants have developed diverse and complex cellular mechanisms. The various aspects of molecular dynamics between plants and environmental stresses will be presented. At the Plant Stress Biology session of KSMCB 2020, the most recent progress on our understanding of the molecular mechanisms by which plants confer resistance to various stresses and pathogens manipulate host defense will be introduced by internationally recognized scientists. Presentations at the Plant Stress Biology session will include molecular genetics, epigenetics and physiology of different model systems of the plant-biotic/abiotic interactions.

Organizer & Chair : Kee Hoon Sohn, Ph.D. (Pohang University of Science and Technology (POSTECH), Korea)
Name(Eng) Organization Nationality Title
Youngsook Lee Pohang University of Science & Technology (POSTECH) Korea Roles of ABC transporters in plant pathogen defense
Tae-Wuk Kim Hanyang University Korea Brassinosteroid-mediated pigment production in Arabidopsis
Ho Won Jung Dong-A University Korea A turnover of nonsense-mediated mRNA decay components is crucial for the Arabidopsis immune responses to Pseudomonas infection
Eui-Hwan Chung Syngenta Crop Protection Korea Differential host protein modifications by bacterial effector proteins and plant immunity
Hye-Young Lee Seoul National University Korea Plant NLRs Target Plasma Membrane Proton Pumps for Executing Membrane Depolarization Leading to Ca2+ Influx and Cell death
Sym.14 Cellular Stress Response and Cell Fate
October 6 (Tue), 15:10-17:20, Channel B
Cells are continuously exposed to various intrinsic or extrinsic stimuli which might cause cellular dysfunction or even death. Cells evolutionally develop defense system to cope with these stresses to restore their functions or to decide to die, which collectively called stress response. The cellular responses might originate from various organelles including endoplasmic reticulum, mitochondria, and lysosome. Given the significant implications of cellular stress responses to human physiology and diseases, we especially focus on the cellular stress response originated from the organelles and the interplay between these responses that ultimately determine the fate of the stressed cells.

Organizers & Chairs : O-Yu Kwon, Ph.D. (Chungnam University, Korea)
Jaeseok Han, Ph.D. (Soonchunhyang University, Korea)
Name(Eng) Organization Nationality Title
Han-Jung Chae Jeonbuk National University Korea Chalcone suppresses tumor growth through Nox4-IRE1α sulfonation-RIDD-axis
Sung Hoon Back University of Ulsan Korea Role of eIF2alpha phosphorylation in autophagy
Hwan Woo Park Konyang University Korea Molecular regulation of Sestrin2 and autophagy and its implications for metabolic diseases
Hiderou Yosida University of Hyogo Japan ER stress response and Golgi stress response
Pia D. Bagamasbad University of the Philippines-Diliman Philippines The molecular basis of the glucocorticoid induction of ERRF11 and its paradoxical role in triple negative breast cancer
Sym.15 Aging Researches from the Basic to the Application
October 6 (Tue), 15:10-17:20, Channel C
Aging is one of the most complex biological processes yet to be poorly understood. Aging is a common risk factor for various chronic diseases such as hypertension, cancer, diabetes and neurodegenerative diseases. Korea experiences the world's fastest transition to oldest society, with expecting to become super-aged society in 2025. Also as with long life expectancy, onset of chronic diseases and medical burden are lowering the quality of life in the elderly world-wide. In last decades, several interventions against aging and aging-associated diseases (AAD) were reported such as anti-aging plasma proteins, senolytic chemicals and potential dietary restriction mimetics. These suggest that dream to live longer without chronic diseases can come true in near future. This Aging Symposium aims to share the latest knowledge and trends in the aging research areas from basic science to intervention for AADs. Since senescence cells (SC) were known to cause organismal aging and the clearance of SC ameliorate AADs and extend the lifespan, it is fast growing research subjects in aging.

Organizers & Chairs : Eun-Soo Kwon, Ph.D. (Aging Research Center, Korea Research Institute of Bioscience and Biotechnology, Korea)
Young-Joon Surh, Ph. D. (Seoul National University, KAST regular member, Korea)
Name(Eng) Organization Nationality Title
Vadim Gladyshev Harvard Medical School USA Quantifying and manipulating the aging process
Okhee Jeon Korea University Korea Targeting cellular senescence as a new approach for post traumatic and age-related
Chuna Kim Korea Research Institute of Bioscience & Biotechnology (KRIBB) Korea Overcoming replicative senescence by alternative lengthening of telomeres
Young Sam Lee Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea Impairment of nucleocytoplasmic
trafficking as a driver of cellular senescence
Sangsoon Park Korea Advanced Institute of Science and Technology (KAIST) Korea An Anti-aging Protein Kinase VRK-1 Promotes Longevity through Activation of AMPK via Phosphorylation
Sym.16 Epigenetic Regulation of Gene Expression
October 6 (Tue), 15:10-17:20, Channel D
This session is composed of 4 speakers who investigate various areas of epigenetic regulation aiming to present to the audience how cellular or organismal functions can be mediated by broad spectrum of epigenetic mechanism. The covered topics include epitranscriptome, chromatin- mediated gene regulation, non-coding RNA.

Organizers & Chairs : Tae-Kyung Kim, Ph.D. (Pohang University of Science and Technology (POSTECH), Korea)
Dae-Sik Lim, Ph. D. (Korea Advanced Institute of Science and Technology (KAIST), KAST regular member, Korea)
Name(Eng) Organization Nationality Title
Yoosik Kim  Korea Advanced Institute of Science and Technology (KAIST) Korea Non-canonical immune response to inhibition of DNA methylation via stabilization of dsRNAs from endogenous retroviruses
Jin-Wu Nam Hanyang University Korea High-confidence noncoding transcriptome maps in cancer and immune cells
Won-Ki Cho   Korea Advanced Institute of Science and Technology (KAIST) Korea Capturing RNA Polymerase II condensate dynamics using super-resolution microscopy in living cell 
Shannon M. Lauberth University of California, San Diego USA Enhancer RNAs are an additional regulatory layer of the epigenome
Jung-Hoon Pyun Sungkyunkwan University Korea Inducible Prmt1 ablation in adult vascular smooth muscle leads to contractile dysfunction and aortic dissection
Sym.17 Genome Engineering Using CRISPR
October 6 (Tue), 15:10-17:20, Channel E
CRISPR-Cas, a prokaryotic adaptive immune system, has been harnessed for genome editing in various species and cell types, including human cells. This session will cover various applications of CRISPR system and its variations.

Organizers & Chairs : Hyongbum Henry Kim, M.D., Ph.D. (Yonsei University, Korea)
Kyoungmi Kim, Ph.D. (Korea University, Korea)
Name(Eng) Organization Nationality Title
Duhee Bang Yonsei University Korea Single-cell analysis of a mutant library generated using CRISPR-guided deaminase
Stannley Qi Stanford University USA Design and program genomics for synthetic biology and therapeutics
Hyongbum Henry Kim Yonsei University Korea Machine learning-based prediction of genome editing outcomes and efficiencies
Kyoungmi Kim Korea University Korea Elimination of unwanted indels at DNA target sites caused by base editors
Jinsong Li Shanghai Institute of Biochemistry and Cell Biology (SIBCB), Chinese Academy of Science China Artificial spermatid'-mediated genome editing
Sym.18 Post-Translational Modification and Proteostasis: From Function to Therapy
October 6 (Tue), 15:10-17:20, Channel F
Cells have evolved stringent protein quality-control equipment for maintenance of protein homeostasis, also referred to as proteostasis. Proteostasis is ensured by a complex network of mechanisms by which protein folding, concentration, localization and association with other molecules can be monitored from synthesis to degradation of proteins. Post-translational modifications (PTMs) are one of the protein quality-control machineries to ensure proteostasis and have essential roles in a wide variety of cellular activities, including protein translation and degradation, control of cell cycle, cell fate decisions, signal transduction, stress responses and cell-to-cell communications. Intriguingly, a failure in the maintenance of proteostasis is closely associated with various human diseases. In this symposium, outstanding scientist from USA will present his recent work to understand how to correct them. Intriguingly, he will focus on pathways that are engaged in the control of anti-tumor immunity by PTM, which define cancer responsiveness to external and internal stress. Three leading scientists from Korea will present their recent works on biochemical mechanisms and pharmaceutical means of N-degron pathway (Yong Tae Kwon), targeted protein degradation (Hyun-Suk Lim) and modulation of the proteolytic machinery for proteostasis (Byung-Hoon Lee), followed by a young investigator's presentation. Therefore, this symposium will cover outstanding progresses to explore molecular mechanisms by which proteostasis can be maintained, to determine the relationship between proteostasis and pathogenesis of human diseases and eventually to contribute to therapeutic interventions in human diseases.

Organizers & Chairs : Young Joo Jeon, Ph.D. (Chungnam National University, Korea)
Hyun Kyu Song, Ph.D. (Korea University, Korea)
Name(Eng) Organization Nationality Title
Ze’ev A Ronai Sanford Burnham Prebys Medical Discovery Institute USA Ubiquitin ligases in anti-tumor immunity
Yong Tae Kwon Seoul National University Korea AUTOTAC (autophagy-targeting chimera): a new platform technology in drug development based on targeted protein degradation via autophagy
Hyun-Suk Lim Pohang University of Science & Technology (POSTECH) Korea Targeted degradation of transcription co-activator SRC-1 via the N-degron pathway
Byung-Hoon Lee Daegu Gyeongbuk Institute of Science and Technology (DGIST) Korea Deubiquitination reactions on the proteasome: inherently designed for dynamic proteolysis
Subba Rao Gangi Setty Indian Institute of Science India Alternative cues to restore the intracellular trafficking defects in lysosome storage disorders

October 7 (Wed), 2020

Sym.19 Deep Learning Enhanced Studies on Infection & Antimicrobial Resistance
*Sponsored by Institut Pasteur Korea
October 7 (Wed), 09:00-11:05, Channel A
Deep learning is rapidly advancing many areas of science and technology with success stories in image, text, voice and video recognition, robotics, and autonomous driving. Deep learning methods are part of artificial intelligence (AI) and more specifically representation learning algorithms that attempt to extract and organize discriminative information from diverse large datasets. Applications of deep-learning techniques for modelling complex bioactivity data are beginning to burgeon, but are mostly restricted to the fields of non-communicable, chronic, and congenital rare genetic disorders. To date there are just a few examples applying such techniques to the benefit of diagnostics, and therapeutics for infectious disease. Recognising that these methods are unavoidable for state-of-the-art systems level approaches to biology, we showcase speakers in a session aiming to stimulate how we think of deep learning as a tool for studies in infection and anti-microbial resistance.

Organizer & Chair : Spencer Shorte, Ph.D. (Institut Pasteur Korea, Korea)
Name(Eng) Organization Nationality Title
Sunkyung Lee Korea Research Institute of Chemical Technology (Korea) Korea Data driven research platform for infectious diseases
Peter Horvath Institut of Biochemistry Hungary Life beyond the pixels: image analysis and machine
learning methods for personalized cancer research
Paulo C. Carvalho Oswaldo Cruz Foundation Brazil Machine learning and mass spectrometry as tools for
avoiding a next world outbreak
Donghyun Lee Korea Polytechnic University Korea Predicting infectious disease using deep learning
Christophe Zimmer Institut Pasteur France Deep learning approaches for biological and medical
Sym.20 Glycosylation: Sweet-Bitter Symphony in a Sweet World
October 7 (Wed), 09:00-11:10, Channel B
Glycobiology is the study of the structure, biosynthesis, biology, and evolution of glycans (also called carbohydrates, saccharides, or sugar chains) that are widely distributed in nature in all living life forms and of the proteins that recognize them. Glycans are one of the four main families of organic molecules of cells with nucleic acids, proteins, and lipids. Like protein phosphorylation, glycosylation is a metabolic process that alters protein structure and function. Glycans are directly involved in virtually every disease affecting humankind, including inflammation, infectious disease, cancer, diabetes, and neurodegeneration. In this symposium, we will introduce novel findings in the field of glycoscience and further discuss the importance of glycoscience in biology, chemistry, and many other areas.

Organizer & Chair : Won Ho Yang, Ph.D. (Glycosylation Network Research Center, Yonsei University, Korea)
Name(Eng) Organization Nationality Title
Jamey Marth Sanford-Burnham-Prebys Medical Discovery Institute / UC Santa Barbara USA Protein Glycosylation in Homeostatic Mechanisms of Inflammatory Diseases
Jin-Hong Kim Seoul National University Korea Stimulating intrinsic repair capacity in osteoarthritic cartilage
Inhee Mook-Jung Seoul National University Korea Amyloid-beta Regulates ER Exit Sites Through O-GlcNAcylation Triggered By Disrupted Calcium Homeostasis
Injae Shin Yonsei University Korea Preparation of glycoconjugates and their bioactivity study
Eunah Kim Yonsei University Korea O-GlcNAcylation on LATS2 disrupts the Hippo pathway by inhibiting its activity
Sym.21 Mitochondria and Human Diseases
October 7 (Wed), 09:00-11:10, Channel C
Various human diseases are closely related to dysregulated metabolism, which often accompanies and is caused by compromised mitochondria. In this symposium, leading scientists will present novel regulatory mechanisms of the mitochondrial functions crucial for maintaining cellular homeostasis, how dysregulated mitochondria perturb cellular metabolic homeostasis to support the onset and progression of the intractable human diseases, and how we target mitochondrial proteins to develop therapeutics.

Organizer & Chair : Byoung Heon Kang, Ph.D. (Ulsan National Institute of Science and Technology (UNIST), Korea)
Name(Eng) Organization Nationality Title
Hyun-Woo Rhee Seoul National University Korea Identification of tissue-specific mitochondrial biogenesis machinery by in vivo proximity labeling
Kyu-Sang Park Yonsei University Korea Regulation of mitochondrial bioenergetics by matrix calcium in brown adipocyte
Chan Bae Park Ajou University Korea Suppressed expression of LDHB promotes age-related hearing loss via aerobic glycolysis
Markus D. Siegelin Columbia University USA AURKA Inhibition Drives Oxidative Energy Metabolism and is Synthetically Lethal with Fatty Acid Oxidation Inhibition in Glioblastoma Model Systems
Jeeyun Chung Harvard University  USA Identification of the protein machinery for lipid droplet formation
Sym.22 Neural Ensemble Mechanism Underlying Brain Function
October 7 (Wed), 09:00-11:10, Channel D
How specific cell ensemble supports brain function is poorly understood. The purpose of this symposium is to introduce and discuss the recent advances in our understanding of how specific cell ensemble supports memory and memory-guided behavior such as decision making. The researchers who have been actively studying this important topic and published critical papers were invited as a speaker to the symposium. The talks in this session will provide research data that address such important question.

Organizer & Chair : Jin-Hee Han, Ph.D. (Korea Advanced Institute of Science and Technology (KAIST), Korea)
Name(Eng) Organization Nationality Title
Yong Seok Lee Seoul National University Korea Fear memory engram in the cerebellum
C. Justin Lee Institute for Basic Science (IBS) Korea Activation of Astrocytic m-Opioid Receptor Causes Conditioned Place Preference
Min Whan Jung Center for Synaptic Dysfunctions, Institute for Basic Science Korea Remembering rewarding futures: hippocampal role in reinforcing valuable sequences
Jin-Hee Han Korea Advanced Institute of Science and Technology (KAIST) Korea Persistence of fear memory depends on a delayed elevation of BAF53b and FGF1 expression
Yoon Seok Kim Stanford University USA Structural Foundations of Optogenetics
Sym.23 Targeting the Tumor Microenvironment & Cancer Immunotherapy
October 7 (Wed), 09:00-11:10, Channel E
This session compose: (I) PD-1 related immunoediting in cancer cells (ii) breast cancer cells, (III) CAR-T cells response (IV) GBM (V) understanding of the NK cell therapy and & tumor microenvironment (TME). The tumor microenvironment is a heterogeneous tissue that in addition to tumor cells, contain tumor-associated cell types such as immune cells, fibroblasts, and endothelial cells. Tumor growth creates hypoxia, oxidative stress and acidosis within the TME triggering an adjustment of the extracellular matrix (ECM), a response from neighbor stromal cells (e.g., fibroblasts) and immune cells (lymphocytes and macrophages), inducing angiogenesis and, ultimately, resulting in metastasis. And also, increased understanding of the T, NK cell response to TME has provided a better nderstanding of their impaired function in tumors which may aid in the development of novel immunotherapeutic strategies to enhance T, NK cell responses in cancer patients.

Organizer & Chair : Sang-Kyu Ye, Ph.D. (Seoul National University, Korea)
Name(Eng) Organization Nationality Title
Taku Okazaki The University of Tokyo Japan Regulation of autoimmunity and cancer immunity by inhibitory co-receptors
Hyeong-Gon Moon Seoul National University Korea Deciphering breast cancer microenvironment by using patient-derived xenograft models
Tae Woo Kim Korea University Korea LC3B upregulation by NANOG promotes immune resistance and stem-like property of immune-edited tumor cells through hyperactivation of EGFR signaling
Jong Bae  Park  National Cancer Center Korea Molecular switches in cancer stem cells drive tumor progression through the cooperation with immune system
Sang-Kyu Ye Seoul National University Korea Highlighted STAT3 as a potential drug target for cancer therapy & tumor microenvironment
June-Yong Lee New York University(NYU) Korea Serum Amyloid A Proteins Induce Pathogenic T-helper 17 (Th17) Immune Program and Promote Chronic Inflammation and Cancer
Sym.24 Stem Cell Based Disease Modeling
October 7 (Wed), 09:00-11:10, Channel F
Human pluripotent stem cells (hPSCs) are not only the important cell source for regenerative medicine but also for disease modeling due to their pluripotency. Establishment of hPSCs with genetic mutations of patients enables the researcher to produce the differentiated cells with pathogenic phenotypes, which would be important cell source for mechanistic study as well as cellular platform for drug screening. This section will cover the recent advance of stem cell based disease modeling and show the future direction in this field of science.

Organizers & Chairs : Kye-Seong Kim, Ph.D. (Hanyang University, Korea)
Hyuk-Jin Cha, Ph.D. (Seoul National University, Korea)
Name(Eng) Organization Nationality Title
Tomoya Kitani  Kyoto Prefectural University of Medicine  Japan Cardiovascular disease modeling and translational research using human induced pluripotent stem cells: opportunity and challenge
Sang-Hun Lee Hanyang University Korea Human DNAJC6 Parkinson disease model reveals disruption of a WNT-LMX1A regulatory loop during midbrain development
Jaecheol Lee Sungkyunkwan University Korea Disease modeling of LMNA-related dilated cardiomyopathy using patient specific induced pluripotent stem cells
Hyuk-Jin Cha Seoul National University Korea Scarless enriched selection of genome edited human pluripotent stem cells using induced drug resistance 
Keun-Tae Kim Seoul National University Korea Intracellular glycogen synthesis modulates Ampk activity to maintain naïve embryonic stem cells
Young Investigator's Session 1
October 7 (Wed), 13:10-14:00, Channel E

Organizer & Chair : Yun Soo Bae, Ph.D. (Ewha Women's University, Korea)
Name(Eng) Organization Nationality Title
Sujin Kim Korea Advanced Institute of Science and Technology (KAIST) Korea Mitochondrial dsRNAs Activate PKR and TLR3 to Promote Chondrocyte Degeneration in Osteoarthritis
Ju-Hyeon Bae Sungkyunkwan University Korea Conditional deletion of Cdon in muscle stem cells results in defective muscle regeneration due to perturbed muscle stem cell function 
Byungjin Lee Chungnam National University Korea Time-Resolved Microfluidic Sample Preparation for Cryo-Em Structural Analysis of Biomolecular Assemblies
Tae-Yong Choi Korea Brain Research Institute (KBRI) Korea Separate Medial Prefrontal Cortex Outputs Oppositely Orchestrate Social Dominance Behavior
Seong-Beom Han Korea University Korea Integrin-mediated Single Molecular Force Dependent Cell Migration
Young Investigator's Session 2
October 7 (Wed), 13:10-14:00, Channel F

Organizer & Chair : Yonghwan Kim, Ph.D. (Sookmyoung Women's University, Korea)
Name(Eng) Organization Nationality Title
Akhtar Ali Konkuk University Korea HOS15 Negatively regulates ABA Signaling and Drought Stress in Arabidopsis
Jineun Kim Korea Advanced Institute of Science and Technology (KAIST) Korea Biphasic response of CRF neurons encoding valence from the external and internal world
Hahn Nahmgoong Seoul National University Korea Characterization of Adipose Stem Cells through Single Cell RNA-seq
Hanee Lee Seoul National University Korea Novel Roles of the Hippo Pathway in Structural Maintenance of C. elegans  Neurons:  A Genetic Model of Premature Aging-related Neurodegeneration
Hae Ryung Chang Sookmyung Women's University Korea Hypomorphic Mutations in TONSL Cause SPONASTRIME Dysplasia