ICKSMCB 2023 / 2023 International Conference of the Korean Society for Molecular and Cellular Biology / September 28 - 30, 2023 / ICC JEJU

Symposia

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November 6Mon, 2023

Sym. 01 Plant-environmental interaction
Plants are exposed to ever-changing environments and numerous attacks, and various survival strategies have been developed accordingly. In recent years, remarkable progress has been made in understanding survival strategies of plants against biotic and abiotic stresses. The dynamic roles of cell wall components such as lignin and suberin in the response to various stresses have been elucidated, and novel secretory pathways for the monomeric components have been suggested. The molecular links between stress and development, particularly flowering time, have been elucidated. In addition, the mechanisms of intracellular NLR immune receptors that recognize pathogen-secreted effector proteins and activate immune responses in plants have been elucidated, broadening our understanding of plant immune responses. These new discoveries break through the limitations of traditional view and opens up new horizons, the details of which will be presented in this session.

Co-organizer: Doil Choi, Ph.D. (Seoul National University, Korea)

Co-organizer: Nam-Chon Paek, Ph.D. (Plant Genomics and Breeding Institute, Korea)
Organizer: Yuree Lee, Ph.D. (Seoul National University, Korea)
Chair: Kee Hoon Sohn, Ph.D. (Seoul National University, Korea)
Name(Eng) Organization Nationality Title
Ohkmae K. Park, Ph.D. Korea University Korea Roles of autophagy in plant defense
Kee Hoon Sohn, Ph.D. Seoul National University Korea Exploring the disease resistance genes conferring a novel pathogen recognition specificity in wild Solanum species
Marie Barberon, Ph.D. University of Geneva Switzerland Plasticity of root permeability for nutrient acquisition
Hee Jin Park, Ph.D. Chonnam National University Korea SOS3, a calcium-binding protein: a key regulator of flowering time and saline stress response
Soohyun Oh, Ph.D. Seoul National University Korea Evolutionary conserved NLRs and effectors enable plant to recognize wide range of non-adapted pathogen species
Sym. 02 Young investigators in Womens Bioscience Forum
This symposium is KSMCB-Women Bioscience Forum (WBF) co-session which introduces outstanding new members as early career women scientists working in the diverse fields of molecular and cellular biology. We expect this session would be effective for discussing recent state-of-art research of young women scientists and further implications in biological sciences and the treatment of a number of diseases.

Organizer: YunJae Jung, M.D., Ph.D. (Gachon University, Korea)
Co-chair: KyeongJin Kim, Ph.D. (Inha University, Korea)
Name(Eng) Organization Nationality Title
Ji-Hyun Lee, Ph.D. Institute for Basic Science Korea Stem cell regulation upon tissue injury in the stomach
Hye Jin Kang, Ph.D. Yonsei University Korea A multiplexed GPCR screening platform that sheds light on new biology
Haejin Yoon, Ph.D. UNIST Korea Dynamic regulation of mitochondrial metabolism in metabolic disease
Ye-Ji Bang, Ph.D. Seoul National University Korea Microbiota-induced vitamin a transport and its role in immunity
Hijai Regina Shin, Ph.D. University of California, Berkeley USA How lysosomal cholesterol sensing mechanism translates to mTORC1 signaling
Sym. 03 Mitonuclear communication
Cellular metabolism is maintained by crosstalk between mitochondria and nucleus. Nucleus can regulate mitochondrial functions by expressions of mitochondrial proteins; mitochondria can exert alterations of nuclear transcriptions via metabolism. These antegrade and retrograde signaling are essential for maintaining homeostasis upon cellular stress. In this symposium, leading scientists in mitochondrial biology will present the latest discoveries and therapeutic applications of Mitonuclear communication.

Co-organizer: Joo-Yeon Yoo, Ph.D. (POSTECH, Korea)

Organizer: Jun NAMKUNG, M.D., Ph.D. (Yonsei University, Korea)
Co-chair: Cheol-Sang Hwang, Ph.D. (Korea University, Korea)
Name(Eng) Organization Nationality Title
Hyon-Seung Yi, M.D., Ph.D. Chungnam National University Korea Implication of mitoribosomal defects in fatty liver disease and liver cancer
Hyongjong Koh, Ph.D. Dong-A University Korea Drug repositioning of mitochondria-targeted anti-cancer agents
Kyu-Sang Park, M.D., Ph.D. Yonsei University Korea Potential role of methionyl-tRNA formyltransferase in mitonuclear signaling
Changhan David Lee, Ph.D. University of Southern California Korea Microproteins and the bacterial origin of mitochondrial communication
Yonghoon Kwon, Ph.D. Gwangju institute of Science and Technology Korea Illuminating spatial organization of GPCR signaling by genetically encoded biosensors in the living cell
Sym. 04 Translational research on cancer and inflammation
Translational science is a rapidly growing discipline in the biomedical field. The goal of translational science is eventually to promote the discovery of new diagnostic tools and treatments by combining disciplines, resources, expertise, and techniques of basic research and clinical fields. The most recent developments in translational research on cancer and inflammation will be the primary focus of this session. The molecular mechanisms of cancer and inflammation, the role of genetics and epigenetics, and new developments in translational medicine will be discussed as topics. In this session, we will provide an overview of the most recent research on cancer and inflammation, discuss the cellular processes that cause cancer and inflammation, and investigate the roles that genetics and epigenetics play in the development of cancer and inflammation. We hope that participants will leave with an understanding of the most recent findings from research on cancer and inflammation, especially cellular processes that underlie cancer and inflammation and potential genetic and epigenetic risk factors for cancer and inflammation in our bodies.

Organizer & Chair: Han Sang Kim, M.D., Ph.D. (Yonsei University, Korea)
Organizer: Ji Eun Oh, M.D., Ph.D. (KAIST, Korea)
Name(Eng) Organization Nationality Title
Han Sang Kim, M.D., Ph.D. Yonsei University Korea Single-cell analysis reveals immune traits associated with poor prognosis in Fusobacterium-inferected colorectal cancer
Youngil Koh, M.D., Ph.D. Seoul National University Hospital Korea Role of clonal hematopoiesis in various human disease
Ayuko Hoshino, Ph.D. University of Tokyo Japan Exosomal protein-mediated inter-organ communication: roles in disease etiology and biomarker potential
Min Kyung Jung, Ph.D. Institute for basic science Korea Memory T cell responses elicited by SARS-CoV-2 infection and vaccination
Joon Seok Park, Ph.D. Harvard Medical School, Harvard University USA Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance
Sym. 05 Understanding evolution through the lens of genomics
Evolutionary genetics is a thriving discipline that investigate the genetic past of a population of a species using genome sequence variation data. Through the unifying lens of the mathematical theory of genome sequence evolution, evolutionary geneticists study a wide range of taxa across the tree of life from diverse perspectives, concerning phylogeny, history, ecology, and function. In this session, we will showcase the far-reaching diversity of evolutionary genetics with presentations by four prominent scholars, ranging from human history (Dr. Kae Koganebuchi) to virus evolution (Prof. Yuseob Kim) to green algae genomes and physiology (Prof. Eunsoo Kim) to evolution and development of the neural system (Prof. Daehan Lee). From these presentations, we would like to show the core questions of evolutionary genomics: i.e. the genetic basis of biological diversity, history, and function.

Organizer: Choongwon Jeong, Ph.D. (Seoul National University, Korea)
Chair: Seunggwan Shin, Ph.D. (Seoul National University, Korea)
Name(Eng) Organization Nationality Title
Kae Koganebuchi, Ph.D. The University of Tokyo Japan Human genomic insights into the historical population dynamics of the Ryukyu Islands, Japan
Yuseob Kim, Ph.D. Ewha Womans University Korea Seasonal oscillation of genome-wide allele frequencies can be explained by interaction between demographic and fitness fluctuations
Eunsoo Kim, Ph.D. Ewha Womans University Korea Endogenous viral elements in the green algal bacterivore Cymbomonas tetramitiformis
Daehan Lee, Ph.D. Sungkyunkwan University Korea Eco-Evo-Devo: the greatest show on earth
Namwoo Kim Institute for Basic Science Korea Short-range end resection requires ATAD5-mediated PCNA unloading for faithful homologous recombination
Sym. 06 Functional diversity of RNA species
The discovery of non-coding RNAs challenged the principles of the central dogma which classified RNAs as merely messengers of DNA-encoded genetic information. Through their structural and functional diversities, RNAs are involved in nearly all biological processes and emerge as key molecules in supporting biological complexity. Recent evidence indicates the presence of additional flavors to the classical definition of coding/non-coding RNAs (e.g., circular RNA, tRNA-derived small non-coding RNA), elucidating novel principles of their biogenesis, activity, and metabolism. RNA molecules and their binding proteins also serve as substrates of biomolecular condensates (e.g., stress granules) that are important for cellular homeostasis and highly relevant to neurodegenerative diseases. This symposium will discuss recent advances in our understanding of RNA biology accordingly.

Co-organizer: Jong-Seo Kim, Ph.D. (Seoul National University, Korea)

Co-organizer: Yoon Ki Kim, Ph.D. (KAIST, Korea)
Organizer & Chair: Yoosik Kim, Ph.D. (KAIST, Korea)
Organizers : Chunghun Lim, Ph.D. (KAIST, Korea)
Yoosik Kim, Ph.D. (KAIST, Korea)
Jong-Seo Kim, Ph.D. (Seoul National University & Institute for Basic Science, Korea)
Yoon Ki Kim, Ph.D. (KAIST, Korea)
Chair: Yoosik Kim, Ph.D. (KAIST, Korea)
Name(Eng) Organization Nationality Title
Yoon Ki Kim, Ph.D. KAIST Korea Internal translation initiation mediated by eIF4A3 in circular RNAs
Ling-Ling Chen, Ph.D. SIBCB, Chinese Academy of Sciences China Dissect the ultrastructure and regulation of the human nucleolus
Hak Kyun Kim, Ph.D. Chung-Ang University Korea A transfer RNA-derived small RNA upregulates gene expression at the level of post-transcription and translation
Youngdae Gwon, Ph.D. Sungkyunkwan University Korea Mechanistic link between RNP granule and cellular senescence
Jane Jung, Ph.D. Yonsei University Korea mRNA transport, translation, and decay in adult mammalian central nervous system axons

November 7Tue, 2023

Sym. 07 Organelle stress and application to human diseases
Cells are continuously exposed to various intrinsic or extrinsic stimuli which might cause cellular dysfunction or even death. Cells evolutionally develop defense system to cope with these stresses to restore their functions or to decide to die, which collectively called stress response. The cellular responses might originate from various organelles including endoplasmic reticulum, mitochondria, and lysosome. Given the significant implications of cellular stress responses to human physiology and diseases, we especially focus on the cellular stress response originated from the organelles and the interplay between these responses that ultimately determine the fate of the stressed cells.

Co-organizer: Jeong Ho Lee, Ph.D. (KAIST, Korea)
Organizer: Jaeseok Han, Ph.D. (Soonchunhyang University, Korea)
Chair: Sung Hoon Back, Ph.D. (University of Ulsan, Korea)
Name(Eng) Organization Nationality Title
Jonathan Lin, Ph.D. Stanford University USA Mutations in unfolded protein response regulator, ATF6, cause novel deafness-blindness syndrome
Jaeseok Han, Ph.D. Soonchunhyang University Korea The implications of integrated stress responses (IRS) on human diseases
Hanjung Chae, Ph.D. Jeonbuk National University Korea ER stress and ER stress response failure
Jaemin Lee, Ph.D. DGIST Korea ER stress and its associated signaling modulate incretin signaling of pancreatic beta-cells under type 2 diabetes
Kyeonghwan Roh, Ph.D. Seoul National University Korea Lysosomal control of senescence and inflammation through cholesterol partitioning
Sym. 08 Microenvironmental regulation to tumor progression and metastasis
Cancer is a highly heterogeneous disease driven by its complex pathogenesis, which involves diverse genetic or epigenetic dysregulations in numerous functional pathways. Over the past few decades, there have been substantial advances in developing molecular therapy for cancer by elucidating diverse molecular alterations. Tumor microenvironment is created by the tumor and dominated by various tumor-induced interactions, such as inhibition of immune cell functions, apoptosis of anti-tumor effector cells and expansion of cancer stem cells, which are accomplished through the activation of one or several molecular mechanisms. In addition, cancer cell metabolism is characterized by an enhanced uptake and utilization of glucose, a phenomenon known as the Warburg effect. In this session, we will talk about recent advances in understanding cellular and molecular pathways operating in the tumor microenvironment and emerging therapeutic strategies to block tumor progression and metastasis.

Organizer & Chair: Yun-Han Lee, Ph.D.(Keimyung University, Korea)
Name(Eng) Organization Nationality Title
Won-Il Jeong, D.V.M., Ph.D. KAIST Korea Immature myeloid cells and arginase-1 in hepatocelluar carcinoma
Na-Young Song, Ph.D. Yonsei University Korea Oral microbiota-epithelial crosstalk in carcinogenesis
Chul-Hwan Lee, Ph.D. Seoul National University Korea Aberrant heterochromatin regulation by the EZH1 mutation in thyroid cancer
Antonio Iavarone, M.D. University of Miami USA Next-generation multi-omic classification of cancer and therapeutic stratification
Young Joo Jeon, Ph.D. Chungnam National University Korea Ubiquitin and its cousins in cancer: more intricate than initially thought
Seogho Son, Ph.D. Hanyang University Korea HIF1-CCN3 positive feedback loop promotes malignant progression of triple-negative breast cancer
Sym. 09 Metabolic diseases: from mouse models to human therapeutics
This session aims to explore the translation of research findings from animal models to human clinical applications, with a focus on various aspects of metabolic disease research and therapeutic development. The session will feature presentations from four experts in their respective fields. Dr. JK Seong will delve into mouse models in metabolic disease research and highlight recent advancements in genetic manipulation technology and multi-omics research. Dr. Choi will provide an overview of the current status and prospects of anti-obesity drugs and present his recent findings on novel mechanisms of neuronal control of appetite. Dr. TY Li will share insights into the mTOR signaling pathway in mitochondrial metabolism and aging-related diseases. Finally, Dr. JE Son will illustrate the regulatory roles of Irx3 and Irx5 in hypothalamic postnatal neurogenesis and leptin response.

Organizers : Yun-Hee Lee, Ph.D. (Seoul National University, Korea)
Sungsoon Fang, Ph.D. (Yonsei University, Korea)
Chair: Jongsoon Lee, Ph.D. (Soonchunhyang University, Korea)
Name(Eng) Organization Nationality Title
Je Kyung Seong, Ph.D. Seoul National University Korea Exercise effect on metabolic syndrome in animal model via microbiome
Hyung Jin Choi, M.D., Ph.D. Seoul National University Korea Hypothalamic therapeutic targets for obesity: an integrated mouse-monkey-human translational approach
Terytty Yang Li, Ph.D. Fudan University China A lysosomal surveillance response (LySR) that reduces proteotoxicity and extends healthspan
Joe Eun Son, Ph.D. Kyungpook National University Korea Genetic regulation of hypothalamic neurodevelopment and obesity
Yanuar Alan Sulistio, Ph.D. Hanyang University Korea Human hypothalamic neural stem cells transplantation prevents physiological decline in aging mouse by regulating body metabolism
Sym. 10 Recent advances in stem cell biology
Tissue development and homeostasis are governed by stem cells that are able to self-renew and differentiate into multiple types of functional cells. Recently, both embryonic stem cells and adult stem cells are utilized to study the mechanisms of tissue development and regeneration, develop model systems of human diseases, and establish the platforms of therapeutic development. Particularly, cell therapy using induced pluripotent stem cells (iPSCs)-derived differentiated cells has been actively developed and tested in preclinical and clinical settings. In the symposium, topics in iPSCs-derived cell therapy strategy for Parkinsons disease, modeling of early human embryo development, and the regulation of adult skin and intestinal stem cells by micro-environment will be discussed. The lectures will provide scientific as well as therapeutic insights into how stem cells respond to external stimuli to govern proper lineage programs and how we can exploit the processes to cure human diseases.

Co-organizer: Dae-Sik Lim, Ph.D. (KAIST, Korea)
Organizer & Chair: Hanseul Yang, Ph.D.(KAIST, Korea)
Organizer: Jinju Han, Ph.D. (KAIST, Korea)
Name(Eng) Organization Nationality Title
Hyemyung Seo, Ph.D. Hanyang University Korea Application of hiPSC for the treatment of neurodegenerative diseases
Jiwon Jang, Ph.D. POSTECH Korea A dedifferentiation barrier reinforces pluripotency exit by suppressing HERVH retrotransposons
Jerome Mertens, Ph.D. University of California, San Diego USA Direct neuronal reprogramming to study brain aging and alzheimer's disease
Min Kyu Yum, Ph.D. KAIST Korea Tracing cellular dynamics during intestinal tumorigenesis and tissue repair
Hun-Goo Lee, Ph.D. Mass General Hospital, Harvard USA Removing Root Cause of Fragile X syndrome by R-loop mediated mechanisms
Sym. 11 Plant circadian clock: protein dynamics and stress response
The circadian clock is a key mechanism within cells that adjusts to changes in the external environments and regulates rhythmic plant physiology and development. Plants have evolved a circadian clock, enabling them to sense and respond to environmental changes to maintain homeostatic balance. Recently, it has been reported that biological clock factors are involved in the modulation of various signaling to adapt to environmental changes through various protein dynamics at the post-translational levels. These research demands may help explain the links between the circadian clock and environmental response. This symposium will share recent research on dynamic protein behaviors in biological clock mechanisms in plant-environment interactions. We encourage participants to share recent research on the plant circadian clock.

Organizer: Woe-Yeon Kim, Ph.D. (Gyeongsang National University, Korea)
Chair: David Somers, Ph.D. (The Ohio State University, USA)
Name(Eng) Organization Nationality Title
David E. Somers, Ph.D. The Ohio State University USA The essential role of TOC1 phosphorylation in selective gene regulation
Sang Yeol Lee, Ph.D. Gyeongsang National University Korea Integration of circadian rhythms by the chloroplast redox protein in a plant cell
Giltsu Choi, Ph.D. KAIST Korea Epidermal phyB promotes light responses by activating the circadian rhythm
Lei Wang, Ph.D. Chinese Academy of Sciences China CRY2 interacts with PRR9 to orchestrate circadian rhythms in Arabidopsis
Jae Kyoung Kim, Ph.D. KAIST Korea Systematic approach to identify hidden protein-protein interactions for robust circadian rhythms
Ye Young Kim, Ph.D. Seoul National University Korea Cryptochrome 1 (CRY1) Participates in Mitochondria Quality Control for Thermogenesis in Brown Adipose Tissue
Sym. 12 Neural circuit and cognitive behavior
This symposium is composed of four outstanding neuroscientists who are studying neural circuits and cognition. It will talk about various levels of studies that are related to neural circuit mechanisms involved in cognitive behaviors, Sensor development for monitoring neurotransmitters in the synapse, the role of dopamine activity in spatial navigation, neural circuit level computational principle of the tactile perception, and development of high temporal and spatial resolution MRI techniques for monitoring single-cell level activity, in which the topics ranging from synapse to cellular network level neural mechanisms will be covered.
Organizer & Chair: Joonyeol Lee, Ph.D. (Sungkyunkwan University, Korea)
Sung Hyun Kim, Ph.D. (Kyung Hee University, Korea)
Name(Eng) Organization Nationality Title
HyungGoo R Kim, Ph.D. SungKyunKwan University Korea A derivative computation of dopamine circuit facing positive and negative valences
Yulong Li, Ph.D. Peking University China Spying on neurodulation by constructing new genetically-encoded GRAB sensors
Jeehyun Kwag, D.Phil. Seoul National University Korea Neural circuits underlying texture perception in the barrel cortex
Jang-Yeon Park, Ph.D. SungKyunKwan University Korea In vivo direct imaging of neuronal activity at high temporal and spatial resolution
Sunwoo Chung, Ph.D. Seoul National University Korea Ectopic-DNA sensing cGAS-STING immune pathway and microglia modulation in Alzheimer's disease
Sym. 13 Industry-academia collaboration symposium
Problem to be solved: When transferred directly from academia or research institutes to industry in the form of start-up or technology transfer, there are often cases where previously identified data are not reproduced in the industry or show different results. This can cause major problems not only in industry but also in academia/research institutes. We would like to discuss how to facilitate data translation between academia and industry, or whether there is any way to overcome these problems.
In addition, we would like to present a new academia-industry collaboration model by considering how to transfer and grow academia-industry technology without any trial and error through early technology transfer through the academia-industry collaboration process.

Organizers: Chong Hyon Yong, Ph.D. (Macrogen, Korea)
Shin Jungseob, M.D. (GPCR, Korea)
Chair: James Jungkue Lee, M.S. (Bridge Biotherapeutics, Inc., Korea)
Name(Eng) Organization Nationality Title
Ilhan Kim, M.S. KB Investment Korea Considerations for company-building from academia and financing
Doo Young Jung, Ph.D. Pinotbio, Inc. Korea Strengths and limitations of biotech-academia collaborations from industry perspective
Won-Ki Huh, Ph.D. Seoul National University Korea Biotech startup story: case of GPCR Therapeutics, Inc.
James Jungkue Lee, M.S. Bridge Biotherapeutics, Inc. Korea Various collaboration models between academia and industry in Korea and USA
Panel discussion
- How can we proactively prevent, check, or resolve data outages?
- How should a patent strategy be established to fully secure technology rights?
- Is there a process that needs to be improved when transferring industry-academia technology? What is the alternative?
- What would be an alternative to a desirable industry-academic collaboration model in a new investment environment?
Sym. 14 Vision restoration: past and future
Vision is the primary sensory system of human and its impairment affects daily life most significantly. The patient numbers of retinal degenerative diseases increase dramatically along with the extension of human lifespan. However, proper treatments for majority retinal degenerative diseases are not available yet. Recently, the regenerative medical approaches, which not simply stop degeneration but further recover the vision of the patients, start to get highlights. In this session, the speakers introduce the latest approaches of retinal regeneration from gene therapy to tissue transplantation.

Co-organizer: Daeyoup Lee, Ph.D. (Research Center for Cellular Identity, Korea)
Organizer & Chair: Jin Woo Kim, Ph.D. (KAIST, Korea)
Name(Eng) Organization Nationality Title
Seth Blackshaw, Ph.D. Johns Hopkins University USA Molecular mechanisms controlling neurogenic competence in retinal glia
Serge Picaud, Ph.D. Institut de la Vision France Optogenetic and sonogenetic brain-machine interfaces for visual restoration
Tae Kwann Park, M.D., Ph.D. Soonchunhyang University Korea Intravitreal administration of exosomes derived from human retinal organoids alleviates photoreceptor degeneration in RCS rats by targeting the MAPK pathway
Jin Woo Kim, Ph.D. KAIST Korea Recovering the regeneration potential of mammalian retina
Elina, KC, Ph.D. Chungbuk National University Korea Optogenetic inhibition of the trigeminal ganglion offers pain relief in a trigeminal neuralgia rat model
Sym. 15 Functional characterization of rare Mendelian diseases
Deciphering functional consequences of entire genes in human will lead to the understanding of human physiology and pathogenesis mechanism of diseases. Since the establishment of whole exome/genome sequencing, about five thousands genotype-phenotype relationships were discovered, and this number is rapidly increasing. To confidently reveal phenotypic consequences of a gene, an integrative effort involving various expertise from clinicians, geneticists, and functional biologists are required. In this session, we will present ongoing examples for such goal.

Organizer & Chair : Sung-Gyoo Park, Ph.D. (Seoul National University, Korea)
Co-chair: Woong Sun, Ph.D. (Korea University, Korea)
Name(Eng) Organization Nationality Title
Woojoong Kim, M.D. Seoul National University Korea Korean undiagnosed disease program (KUDP): ongoing journey of rare disease research
Andrea Accogli, M.D. McGill University Health Centre (MUHC) Canada Unveiling New Genetic Players in Axon Guidance Defects
Christopher J. Westlake, Ph.D. Center for Cancer Research National Cancer Institute USA A ciliopathy spectrum disorder caused by dysregulation of ciliogenesis initiation
Murim Choi, Ph.D. Seoul National University Korea Elucidating gene and variant function in rare diseases
Jaya Bagaria Sungkyunkwan University Korea Differential condensation of HNRNPK WT and mutants associated with Au-Kline syndrome upon cellular stresses
Sym. 16 Enabling technologies for microbiome structure and function
The microbiome, comprised of the microbiota, its collective genomes called the metagenome, and myriads of macromolecules and metabolites, is an integral part of the biosphere and our body. Members of the microbiota include bacteria, archaea, microbial eukaryotes, and respective viruses. Recent studies reveal that miniscule constituents, mutualistic, commensal, or pathogenic, of the human microbiome play pivotal roles in health and disease. Not only are they important in nutrient digestion and gastrointestinal health, but they are also intimately and intricately involved in metabolism, immunity, development, circulation, and behavior, and modulate them in many ways. The session brings together experts in human microbiome research to overview enabling technologies and scientific achievements, to discuss challenges and opportunities, and to explore novel pharmabiotics candidates that have pharmacological potential for maintaining health or treating diseases.

Organizer & Chair: Jihyun F. Kim, Ph.D. (Yonsei University, Korea)
Soon-Kyeong Kwon, Ph.D. (Gyeongsang National University, Korea)
Name(Eng) Organization Nationality Title
Cholsoon Jang, Ph.D. University of California Irvine USA Microbial metabolome in action
Dong-Woo Lee, Ph.D. Yonsei University Korea Genome-wide multi-omics analysis reveals the nutrient-dependent metabolic features of mucin-degrading gut bacteria
Do Yup Lee, Ph.D. Seoul National University Korea Covarianced landscape of gut microbial-metabolomic structures differentially signatured by dysregulation
Insuk Lee, Ph.D. Yonsei University Korea Cataloging human symbiotic bacteria and viruses
Munhyung Bae, Ph.D. Gachon University Korea Crosstalk between gut bacteria-derived small molecules and the human immune system
Nuri Cha Hanyang University Korea Drosophila macrophages control hemolymph sugar levels by sensing fructose receptor
Sym. 17 Cellular signaling by primary cilia in development and disease
To understand the role of cilia, which are organelles involved in various intracellular signal transduction processes and the molecular mechanisms of diseases affecting various tissues and organs caused by their defects.

Co-organizer: Eunjoon Kim, Ph.D. (IBS/KAIST, Korea)
Organizer: Seung Tae BAEK, Ph.D. (POSTECH, Korea)
Co-chair: Hyuk Wan Ko, Ph.D. (Yonsei University, Korea)
Name(Eng) Organization Nationality Title
Ji Eun Lee, Ph.D. Sungkyunkwan University Korea Primary cilia in adipocytes are critical to suppress NAFLD by regulating hepatocyte lipogenesis
Ki Woo Kim, Ph.D. Yonsei University Korea Energy homeostasis regulation through neuronal primary cilia
Soo-Hyun Kim, Ph.D. University of London UK Differential regulation of canonical and non-canonical Hedgehog signalling by Ptch1/Boc and Ptch2/Gas1 through cilia-dependent and -independent mechanisms
Jean-Ju Chung, Ph.D. Yale School of Medicine USA Assembly and development of calcium signaling domains in sperm flagella
Mijung Kwon, Ph.D. Ewha Womans University Korea Coping with extra centrosomes: mechanistic insights into the regulation of tumor microenvironment
Hahyun Park, Ph.D. Korea University Korea Developmental toxicity in bifenox-exposed zebrafish embryos mediated by apoptotic signaling and oxidative stress
Sym. 18 Frontiers in cancer cell signaling and metabolism
The main themes of this session are: 1) Explore recent advances in cancer cell metabolism directed by oncogenic PI-3 kinase/Akt signaling pathway; 2) Understand the biological significance of mitochondrial reactive oxygen species (ROS) in cancer cell survival; 3) Uncover the contribution of glutaminolysis to the integrative control of tumor metabolism, hypoxia, and chemoresistance; 4) Highlight the innovative approach to selectively kill cancer cells by modulating toxic metabolites; 5) Identify the role of micropinocytosis in leukemic cancer cell survival and chemoresistance. This session will present the latest research findings and stimulate discussion on the mechanisms of how cellular signaling events and tumor metabolism are functionally linked in cancer cells.

Organizer: Seyun Kim, Ph.D.(KAIST, Korea)
Co-chair: Sung Eun Kim, Ph.D. (Korea University, Korea)
Name(Eng) Organization Nationality Title
Alex Toker, Ph.D. Harvard Medical School USA The PI 3-kinase and AKT signaling pathway in health and disease: from discovery to therapeutics
Ho Jeong Kwon, Ph.D. Yonsei University Korea Unraveling the mitochondrial ROS-cell survival-autophagy link and its translational implications
Jung Min Han, Ph.D. Yonsei University Korea Deciphering glutaminolysis: the connection between metabolic reprogramming, hypoxia and chemoresistance
Dohoon Kim, Ph.D. University of Massachusetts USA The role of toxic metabolic pathways in cancer cells
Sung Eun Kim, Ph.D. Korea University Korea Macropinocytosis promotes NAD+ synthesis for cell survival and FK866 resistance

November 8Wed, 2023


Sym. 19 The biology of viral infection: host interactions and pathogenesis
Viruses are obligate intracellular parasites which rely on their host cells for the energy, macromolecular synthesis machinery, genome replication and particle assembly. Because of this dependence, viruses have evolved a myriad of mechanisms for exploiting normal host cell functions By examining cellular responses to infection, we can gain insights regarding the mechanisms associated with the restriction of virus infection or, in cases where control is ineffective, pathogenesis. Such knowledge is a prerequisite for the successful modulation of these responses to develop direct-acting antivirals targeting viral proteins, or direct and indirect therapies targeting host cell components, which would have a reduced likelihood to allow resistance development. During this session, 4 speakers will discuss topics which cover viral transmission, replication mechanisms, in vivo pathogenesis, host response immunity and viral evasion strategies. The virus models include Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV), Japanese encephalitis virus (JEV), Zika virus (ZIKV) and hepatitis B and E viruses (HBV, HEV). The session will highlight the importance of the One health approach to the human-animal ecosystem and the need to develop research preparedness to enlighten the virus-host interaction of emerging and re-emerging viruses.

Name(Eng) Organization Nationality Title
Alexander Ploss, Ph.D. Princeton University USA New insights into the replicative cycles and species tropism of human hepatitis viruses
Han-Woong Lee, Ph.D. Yonsei University Korea A novel humanized ACE2 mouse model for COVID-19
Dimitri Lavillette, Ph.D. Institut Pasteur Korea France ZIKA virus NS5 SUMOylation on a lineage-specific lysine modulates virus pathogenicity
Wonhee Hur, Ph.D. National Institute of Health Korea The role RNA-binding proteins in functional cure strategies for chronic hepatitis B virus
Sym. 20 Forces in biology
The goal of this symposium is to understand the principles of cellular processes regulating mechanical responses from molecular to cellular levels. This symposium will cover biological thermodynamics; enzyme kinetics and function; ligand-receptor signaling in mechanotransduction by cellular forces; and cell decision making in cell-cell interaction (Regarding conformational change of enzymes, focal adhesion formation, force transmission thru actin networks, force-dependent cellular responses, and receptor trafficking). The audiences are expected to understand the cellular processes of life sciences at the level of molecules and synaptic complexes in cells.

Organizer: Gwangrog Lee, Ph.D. (GIST, Korea)
Chair: Byoung Choul Kim, Ph.D. (Incheon National University, Korea)
Name(Eng) Organization Nationality Title
Young-wook Jun, Ph.D. University of California, San Francisco USA Size, force, and entropy at the cellular interface
Yongdae Shin, Ph.D. Seoul National University Korea The organization and function of biomolecular condensates centered around RNA
Eung-Sam Kim, Ph.D. Chonnam National University Korea Mechanoadaptation of alveolar epithelial cells under cyclic stretches
Byoung Choul Kim, Ph.D. Incheon National University Korea How does integrin tension affect cancer and brain diseases?
Gustavo Pacheco, M.D., Ph.D. University of Virginia USA Integrin mechanotransduction regulates mitochondrial metabolic activity and its spatial localization in collective cell migration
Sym. 21 Genomic impact of transposable elements
Transposable elements (TEs) have been found in a variety of genomes. TEs are a major source of genetic diversity in eukaryotes. TEs have played an important role in the diversification and enrichment of mammalian transcriptomes. These elements are associated with genomic instability, cancer, epigenetics, gene expression, biomarkers, and DNA repair.


Organizer & Chair: Kyudong Han, Ph.D. (Dankook University, Korea)
Name(Eng) Organization Nationality Title
Young-Jun Jeon, Ph.D. Sungkyunkwan University Korea Overcoming strategies for radiation resistance driven by KEAP1-NFE2L2 pathway in lung cancer
Jinchuan Xing, Ph.D. Rutgers, the State University of New Jersey USA Functional impact and implication of mobile DNA elements in the human genome
Hyunjin Koo, Ph.D. Korea Research Institute of Bioscience and Biotechnology Korea Comprehensive genomic landscape of active long terminal repeat retrotransposons in plants
Chang Hyun Nam, M.D. KAIST Korea Widespread somatic L1 retrotransposition in normal colorectal epithelium
Myungkyung Noh, Ph.D. Seoul National University Korea Particulate matter-induced metabolic recoding of epigenetics in macrophages drives pathogenesis of chronic obstructive pulmonary disease
Sym. 22 Neurobiology of emotional and reward memory
Understanding how memories produce behavioral changes is a fundamental goal of neuroscience. To achieve this goal, we need deep appreciation of behavior as well as a detailed knowledge of the underlying underpinnings. Pioneering scientists have established the related fields of behavioral genetics and neural circuitry toward genuine secrets of animal behaviors, associated with emotional and reward memories. These two approaches have recently been combined unprecedentedly, effectively fuelled by powerful new technical tools such as optogenetics. At this symposium, leading researchers studying neurobiology of memory formation and maintenance will present exciting new results and prompt better understanding of cellular and synaptic mechanisms for emotional & reward memories.
Organizer & Chair: Joung Hun Kim, Ph.D. (POSTECH, Korea)
Name(Eng) Organization Nationality Title
Byungkook Lim, Ph.D. University of California San Diego USA Cortical interneuron dynamics underlying drug seeking after withdrawal
Ja-Hyun Baik, Ph.D. Korea University Korea Central amygdala dopamine signaling in food reward
Ja Wook Koo, Ph.D. Korea Brain Research Institute Korea Dopaminergic reward circuit is responsible for effort-based social decision-making behavior
Alan Jung Park, Ph.D. Seoul National University Korea Novel experience facilitates new learning by resetting brain circuitry
Heejin Cho, Ph.D. KAIST Korea Adnp-mutant mice with cognitive inflexibility, CaMKII hyperactivity, and synaptic plasticity deficits
Sym. 23 Bone and cartilage biology and diseases
Bone is a living, growing tissue that composes the basic skeleton of the body and is linked to various biological systems, such as the immune, the nervous, cardiovascular, metabolism, and stem cells. Bone tissue is continuously being remodeled through resorption and formation mediated by the communication of bone cells. Various bone diseases are induced from an imbalance between bone resorption and formation. Therefore, the studies concerning the dynamic structure function and metabolism of bone tissue is necessary for developing therapeutics of bone diseases and maintaining healthy bone. This symposium is providing a better understanding of bone cell functions and of the pathophysiology of bone diseases, and is suggesting new regulatory genes, molecules and mechanisms for therapeutics to treat bone diseases.

Co-organizer: Youngsoo Jun, Ph.D. (GIST, Korea)
Organizer & Chair: Young Yang , Ph.D. (Sookmyung Women's University, Korea)
Name(Eng) Organization Nationality Title
Se Hwan Mun, Ph.D. Sookmyung Women's University Korea Effects of E3 ligase on osteoporosis:
a new potential therapeutic target
Yonghwan Kim, Ph.D. Sookmyung Women's University Korea Identification of novel gene variants leading to skeletal dysplasia
Kyung-Hyun Park-Min, Ph.D. Weill Cornell Medical College, Hospital for Special Surgery USA Targeting bone easters
Nacksung Kim, Ph.D. Chonnam National University Korea The role of CrkII in bone metabolism
Seoyeon Bok, Ph.D. Weill Cornell Medicine USA A multi-stem cell basis for craniosynostosis and calvarial mineralization
Sym. 24 Single-cell immuno-oncology
Single-cell technologies are revolutionizing our fundamental understanding of tumor microenvironment. Especially single-cell analysis enables the dissection of tumor cellular heterogeneity, including tumor, stroma, and immune cells, leading to the identification of novel cell types and measurement of a continuum of intra-tumoral cell states. In this symposium, five speakers will discuss how to apply cutting-edge single-cell technologies for immune-oncology.

Co-organizer: Goo Taeg Oh, D.V.M., Ph.D. (Ewha Womans University, Korea)
Organizer: Jungmin Choi, Ph.D. (Korea University, Korea)
Organizer & Chair: Jae-Hoon Choi, D.V.M., Ph.D. (Hanyang University, Korea)
Co-chair: Daehee Hwang, Ph.D. (Seoul National University, Korea)
Name(Eng) Organization Nationality Title
Ido Amit, Ph.D. Weizmann Institute of Science Israel The power of ONE: immunology in the age of spatial and single cell genomics
Jong Hoon Kim, M.D., Ph.D. Yonsei University Korea The intra-niche activation of CXCL13+CD4+T cells in tertiary lymphoid structure
Seunghee Hong, Ph.D. Yonsei University Korea Fate of T cells in autoimmunity: dissecting atopic dermatitis and psoriasis through single-cell RNA sequencing
Jihwan Park, Ph.D. GIST Korea Single-cell transcriptome analysis of cancer cell plasticity and tumor microenvironment
Won Hee Lee KAIST Korea Single-cell transcriptomic and somatic mutational profiling in a non-alcoholic fatty liver disease mouse model to reveal hepatocellular carcinogenesis
Sym. YI
Name(Eng) Organization Nationality Title
Dae-young Park, Ph.D. Chungbuk National University Korea Structure based innovative approach to analyze aptaprobema
Jongsun Lee KAIST Korea Ribosome rescue factor PELO-1/PELOTA prevents premature aging by enhancing mRNA quality and autophagy in C. elegans and mammals
Chungha Lee KAIST Korea Quantitative whole-embryo imaging at the subcellular level: holotomography of mouse preimplantation embryo development
Sang-Hyeon Mun, Ph.D. Korea University Korea Marchf6 as a key regulator for ER stress and ferroptosis via cytosolic-retained POMC degradation
Soyeon Jeong, Ph.D. Seoul National University Korea Structural studies on the assembly process of nuclear lamins by a mutation and phosphorylation
Sanghyun Sung, Ph.D. Seoul National University Korea Unique traits of two types of alternative lengthening of telomeres in mouse embryonic stem cells