 |
백성희 (서울대학교 자연과학대학/생명과학부)
Prof. Sung Hee Baek has been contributing to the understanding of chromatin dynamics and epigenetic regulatory mechanism in cancer, autophagy, and inflammation. Since she joined the faculty of Seoul National University in 2003, She has been pioneering in the field of epigenetics and chromatin dynamics by focusing on signal-dependent epigenetic regulation of gene expression. She has been leading her Research Center for Epigenetic Code and Diseases. Epigenetics encompass inheritable changes in gene expression profiles that occur without alterations to the genomic DNA sequence. Epigenetic modifications conduct important roles in diverse biological processes that range from regulation of gene expression to human diseases. Her groups aim to define 'the epigenetic code and diseases', investigate causality of the relationship between the epigenetic code and diseases to ultimately screen 'epigenetic drugs' for therapeutic applications. For this, her groups plan to identify novel epigenetic code and regulators, generate their mouse models, define their physiological roles in homeostasis, and explore the mechanisms of their disturbance in epigenetic diseases. In this presentation, her continued efforts to decipher epigenetic code and diseases will be discussed as well as introduction of newly identified signaling crosstalk regulated by epigenetic modifications.
대표논문
- PKCα-LSD1-NF-κB Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response. (2018). Molecular Cell 69, 398-411.
- Epigenetic Control of Autophagy: Nuclear Events Gain More Attention. (2017). Molecular Cell 65, 781-785.
- AMPK-SKP2-CARM1 Signaling Cascade in Transcriptional Regulation of Autophagy. (2016). Nature 534, 553-557.
- KAI1 Maintains Dormancy of Long-Term Hematopoietic Stem Cells Through Interaction with DARC-expressing Macrophage. (2016). Cell Stem Cell 18, 508-521.
- Phosphorylation of LSD1 by PKCα Is Crucial for Circadian Rhythmicity and Phase Resetting. (2014). Molecular Cell 53, 791-805. (Cover Article)
|
학회소개 