학회소개 
| 한국분자·세포생물학회 학술상 생명과학상 수상자 | |
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김재범(서울대학교)
Dr. Jae Bum Kim is a Professor of Biological Sciences at Seoul National University and Director of the Center for Adipocyte Structure and Function, National Leading Research Initiatives in Korea. He obtained his Bachelor and Master’s degree in Science at Seoul National University. Then, he earned his Ph. D. at Harvard University under the mentorship of Dr. Bruce Spiegelman, where he cloned and elucidated ADD1/SREBP1c as a key lipogenic transcription factor. After his postdoctoral fellowship training with Dr. Phillip Sharp at MIT, he joined at School of Biological Sciences, Seoul National University in 2000. His research group has investigated gene expression regulation and signal transduction pathways of lipid and glucose metabolism. Recently, his group has focused on the molecular mechanisms of adipose tissue heterogeneity, immune response, and insulin resistance, which would shed important insights on obesity and its related metabolic diseases. Representative papers |
| 한국분자·세포생물학회 학술상 Molecules and Cells (M&C) 수상자 | |
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김수영(전남대학교)
Arabidopsis Raf-like Kinase Raf10 Is a Regulatory Component of Core ABA Signaling Mol Cells. 42(9):646-660 (2019) Abscisic acid (ABA) is a phytohormone essential for seed development and seedling growth under unfavorable environmental conditions. The signaling pathway leading to ABA response has been established, but relatively little is known about the functional regulation of the constituent signaling components. Here, we present several lines of evidence that Arabidopsis Raf-like kinase Raf10 modulates the core ABA signaling downstream of signal perception step. In particular, Raf10 phosphorylates subclass III SnRK2s (SnRK2.2, SnRK2.3, and SnRK2.6), which are key positive regulators, and our study focused on SnRK2.3 indicates that Raf10 enhances its kinase activity and may facilitate its release from negative regulators. Raf10 also phosphorylates transcription factors (ABI5, ABF2 and ABI3) critical for ABA-regulted gene expression. Furthermore, Raf10 was found to be essential for the in vivo functions of SnRK2s and ABI5. Collectively, our data demonstrate that Raf10 is a novel regulatory component of core ABA signaling. |