학회소개 
| 한국분자·세포생물학회 학술상 생명과학상 수상자 | |
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김윤기 (KAIST)
Dr. Yoon Ki Kim is a Professor in the Dept. of Biological Sciences at Korea Advanced Institute of Science and Technology (KAIST). He earned his Bachelor’s, Master’s, and Ph.D. degrees from Pohang University of Science and Technology (POSTECH), under the mentorship of Prof. Sung Key Jang. During his Master’s and doctoral studies, he investigated the molecular mechanisms underlying translation initiation mediated by the internal ribosome entry site. He then joined Prof. Lynne E. Maquat’s lab as a postdoctoral fellow and delved into the translation-coupled mRNA decay mechanism. During his postdoc, he uncovered a mechanistically unique RNA decay mechanism known as staufen1-mediated mRNA decay. In 2005, he started his own lab at Korea University. Since then, his research has been dedicated to the in-depth exploration of the molecular mechanisms underlying mRNA degradation, translational control, and protein aggregation. Since 2015, he has served as the director of the Center for Molecular Biology of Translation, a National Leading Research Initiatives in Korea. In addition, he is currently a co-CEO of RiboTech, a bio-venture company with a focus on developing therapeutic circular RNAs. In 2022, he moved his lab to KAIST and has since continued to conduct a variety of RNA-related molecular studies, including mRNA modification, circular RNA biogenesis, and translational control. |
| 한국분자·세포생물학회 학술상 Molecules and Cells (M&C) 수상자 | |
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김희수 (부산대)
Expression analyses of miRNAs in hamster lung tissues infected by SARS-CoV-2 Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an infectious disease with multiple severe symptoms, such as fever over 37.5℃, cough, dyspnea, and pneumonia. In our research, microRNAs (miRNAs) binding to the genome sequences of severe acute respiratory syndrome coronavirus (SARS-CoV), middle east respiratory-related coronavirus (MERS-CoV), and SARS-CoV-2 were identified by bioinformatic tools. Five miRNAs (hsa-miR-15a-5p, hsa-miR-15b-5p, hsa-miR-195-5p, hsa-miR-16-5p, and hsa-miR-196-1-3p) were found to commonly bind to SARS-CoV, MERS-CoV, and SARS-CoV-2. We also identified miRNAs that bind to receptor proteins, such as ACE2, ADAM17, and TMPRSS2, which are important for understanding the infection mechanism of SARS-CoV-2. The expression patterns of those miRNAs were examined in hamster lung samples infected by SARS-CoV-2. Five miRNAs (hsa-miR-15b-5p, hsa-miR-195-5p, hsa-miR-221-3p, hsa-miR-140-3p, and hsa-miR-422a) showed differential expression patterns in lung tissues before and after infection. Especially, hsa-miR-15b-5p and hsa-miR-195-5p showed a large difference in expression, indicating that they may potentially be diagnostic biomarkers for SARS-CoV-2 infection. |